Biological functions of macrophage-derived Wnt5a, and its roles in human diseases

Yue Shao; Qianqian Zheng; Wei Wang; Na Xin; Xiaowen Song; Chenghai Zhao

doi:10.18632/oncotarget.11874

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Biological functions of macrophage-derived Wnt5a, and its roles in human diseases

Yue Shao, Qianqian Zheng, Wei Wang, Na Xin, Xiaowen Song and Chenghai Zhao _

PDF | HTML | How to cite

Oncotarget. 2016; 7:67674-67684. https://doi.org/10.18632/oncotarget.11874

Metrics: PDF 2849 views | HTML 5550 views | ?

Abstract

Yue Shao1, Qianqian Zheng1, Wei Wang1, Na Xin1, Xiaowen Song1 and Chenghai Zhao1

1 Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China

Correspondence to:

Chenghai Zhao, email:

Keywords: Wnt5a, β-catenin, macrophage, angiogenesis, lymphangiogenesis

Received: December 08, 2015 Accepted: August 27, 2016 Published: September 06, 2016

Abstract

Wnt5a is implicated in development and tissue homeostasis by activating β-catenin-independent pathway. Excessive production of Wnt5a is related to some human diseases. Macrophage recruitment is a character of inflammation and cancer, therefore macrophage-derived Wnt5a is supposed to be a player in these conditions. Actually, macrophage-derived Wnt5a maintains macrophage immune function, stimulates pro-inflammatory cytokine release, and induces angiogenesis and lymphangiogenesis. Furthermore, macrophage-derived Wnt5a is involved in insulin resistance, atherosclerosis and cancer. These findings indicate that macrophage-derived Wnt5a may be a target in the treatment of these diseases. Notably, unlike macrophages, the exact role of macrophage-derived Wnt5a in bacterial infection remains largely unknown.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 11874

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Biological functions of macrophage-derived Wnt5a, and its roles in human diseases

Abstract