The Oncosearch | Oncotarget

COVID vaccination and post-infection cancer signals: Evaluating patterns and potential biological mechanisms Review

Charlotte Kuperwasser, Wafik S. El-Deiry

Published Mar 30, 2026 · Vol. 17, No. 1 · pp. 1-29

Keywords: COVID, vaccine, cancer, infection, lymphoma, leukemia, sarcoma, carcinoma

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Kyle R. Cron, Ping Fang, Oanh Pham, Julie Janes, John Brandenburg, William Lu, Jonathan Zhu, Bret Peterson, Sara Tribble, Haixing Kehoe, Anastasia Makarova, Alex Iannello, Jean Chan, Justin Skoble, Hailey He, Chris Rae, Christopher D. Thanos, Akshata R. Udyavar

Published Oct 2, 2025 · Vol. 16, No. 1 · pp. 721-740

Keywords: tumor microenvironment, bacterial vector, myeloid cells, STING, IL-15

Trained and ready - the case for an inflammatory memory for hematopoietic stem and progenitor cells in the AML niche Research Perspective

Ding-Wen Chen, Eric K. Wafula, Peter Kurre

Published Aug 17, 2024 · Vol. 15, No. 1 · pp. 609-613

Keywords: hematopoietic stem and progenitor cells, acute myeloid leukemia, inflammation, innate immune reprogramming, trained immunity

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines Research Paper

Mathew Lozinski, Nikola A. Bowden, Moira C. Graves, Michael Fay, Bryan W. Day, Brett W. Stringer, Paul A. Tooney

Published Jan 5, 2024 · Vol. 15, No. 1 · pp. 1-18

Keywords: glioblastoma, DNA damage response, ataxia-telangiectasia and rad3-related protein, radiation therapy, temozolomide

Targeting GITR in cancer immunotherapy – there is no perfect knowledge Research Perspective

Diwakar Davar, Roberta Zappasodi

Published Jun 12, 2023 · Vol. 14, No. 1 · pp. 614-621

Keywords: cancer, immunotherapy, programmed death-1 (PD-1), cytotoxic T-lymphocyte Antigen-4 (CTLA-4), glucocorticoid-induced TNFR-related protein (GITR)

IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells Research Paper

Chau P. Tran, Michelle Scurr, Louise O’Connor, Jon N. Buzzelli, Garrett Z. Ng, Sharleen Chung Nien Chin, Lincon A. Stamp, Toshinari Minamoto, Andrew S. Giraud, Louise M. Judd, Philip Sutton, Trevelyan R. Menheniott

Published May 12, 2022 · Vol. 13, No. 1 · pp. 785-799

Keywords: IL-33, gastric cancer, tumorigenesis, mast cells, macrophages

Exploring the synergistic effects of cabozantinib and a programmed cell death protein 1 inhibitor in metastatic renal cell carcinoma with machine learning Research Paper

Ignacio Durán, Daniel Castellano, Javier Puente, Lidia Martín-Couce, Esther Bello, Urbano Anido, José Manuel Mas, Luis Costa

Published Jan 20, 2022 · Vol. 13, No. 1 · pp. 237-256

Keywords: machine learning, cabozantinib, renal cell carcinoma, tumour microenvironment, systems biology

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers Research Perspective

Austin R. Dosch, Walid K. Chatila, Yuguang Ban, Anna Bianchi, Nilesh U. Deshpande, Iago De Castro Silva, Nipun B. Merchant, Jashodeep Datta

Published Jun 1, 2021 · Vol. 12, No. 20 · pp. 2104-2110

Keywords: Ras-p53 cooperativity, Ras, TP53, immune, gastrointestinal cancer

Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems? Editorial

Tomohiro Kagi, Takuya Noguchi, Atsushi Matsuzawa

Published May 4, 2021 · Vol. 12, No. 13 · pp. 1321-1322

Keywords: gefitinib, interstitial pneumonitis, tyrosine kinase inhibitor, inflammation, NLRP3 inflammasome

Predicting clinical outcomes using cancer progression associated signatures Research Paper

Jared Mamrot, Nathan E. Hall, Robyn A. Lindley

Published Mar 30, 2021 · Vol. 12, No. 8 · pp. 845-858

Keywords: innate immunity, biomarker, mutagenesis, oncogenesis, cancer progression

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma Research Paper

Rolando Pérez-Lorenzo, Stephanie O. Erjavec, Angela M. Christiano, Raphael Clynes

Published Jan 6, 2021 · Vol. 12, No. 2 · pp. 66-80

Keywords: anti-tumor antibodies, targeted therapy, immunotherapy, combination therapies, melanoma

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020 · Vol. 11, No. 46 · pp. 4201-4223

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women Research Paper

Angel Núñez-Marrero, Nelly Arroyo, Lenin Godoy, Mohammad Zillur Rahman, Jaime L. Matta, Julie Dutil

Published Aug 5, 2020 · Vol. 11, No. 37 · pp. 3420-3431

Keywords: breast cancer, interleukin-12 (IL-12), IL-12 signaling, genetic association, single nucleotide polymorphisms

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

Stefan Nagel, Claudia Pommerenke, Roderick A.F. MacLeod, Corinna Meyer, Maren Kaufmann, Hans G. Drexler

Published Jul 15, 2020 · Vol. 11, No. 34 · pp. 3208-3226

Keywords: homeobox, NKL-code, T-ALL, LL-100, Th17

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Brandon Yi Da Hoong, Yunn Hwen Gan, Haiyan Liu, Ee Sin Chen

Published Jun 30, 2020 · Vol. 11, No. 30 · pp. 2930-2955

Keywords: cyclic GMP-AMP synthase, stimulator of interferon, cGAS, STING, interferon

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

Yue Guan, Christopher B. Chambers, Taylor Tabatabai, Ha Hatley, Kristin R. Delfino, Kathy Robinson, Shaheen R. Alanee, Sophia Ran, Donald S. Torry, Andrew Wilber

Published Jun 12, 2020 · Vol. 11, No. 26 · pp. 2571-2585

Keywords: kidney cancer, innate immunity, natural killer cells, immunosuppression, angiogenesis

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. McNulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 216-236

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

Weng In Leong, Rachel Y. Ames, Jessica M. Haverkamp, Laura Torres, Janine Kline, Ashil Bans, Lauren Rocha, Marilena Gallotta, Cristiana Guiducci, Robert L. Coffman, Mary J. Janatpour

Published Dec 31, 2019 · Vol. 10, No. 68 · pp. 7220-7237

Keywords: TLR9, SD-101, cyclophosphamide, immune therapy, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

COVID vaccination and post-infection cancer signals: Evaluating patterns and potential biological mechanisms Review

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Trained and ready - the case for an inflammatory memory for hematopoietic stem and progenitor cells in the AML niche Research Perspective

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines Research Paper

Targeting GITR in cancer immunotherapy – there is no perfect knowledge Research Perspective

IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells Research Paper

Exploring the synergistic effects of cabozantinib and a programmed cell death protein 1 inhibitor in metastatic renal cell carcinoma with machine learning Research Paper

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers Research Perspective

Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems? Editorial

Predicting clinical outcomes using cancer progression associated signatures Research Paper

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women Research Paper

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

COVID vaccination and post-infection cancer signals: Evaluating patterns and potential biological mechanisms Review

ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response Research Paper

Trained and ready - the case for an inflammatory memory for hematopoietic stem and progenitor cells in the AML niche Research Perspective

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines Research Paper

Targeting GITR in cancer immunotherapy – there is no perfect knowledge Research Perspective

IL-33 promotes gastric tumour growth in concert with activation and recruitment of inflammatory myeloid cells Research Paper

Exploring the synergistic effects of cabozantinib and a programmed cell death protein 1 inhibitor in metastatic renal cell carcinoma with machine learning Research Paper

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers Research Perspective

Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems? Editorial

Predicting clinical outcomes using cancer progression associated signatures Research Paper

Improved therapeutic efficacy of unmodified anti-tumor antibodies by immune checkpoint blockade and kinase targeted therapy in mouse models of melanoma Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women Research Paper

The NKL-code for innate lymphoid cells reveals deregulated expression of NKL homeobox genes HHEX and HLX in anaplastic large cell lymphoma (ALCL) Research Paper

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Renal cell tumors convert natural killer cells to a proangiogenic phenotype Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper