Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.
As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.
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As noted in the abstract of this paper, lifelong hematopoiesis is sustained by the crosstalk between hematopoietic stem and progenitor cells (HSPCs) and specialized bone marrow niches. Acute myeloid leukemia (AML) disrupts this balance, as leukemic blasts secrete factors that remodel the bone marrow into a self-reinforcing leukemic niche. Additionally, HSPCs are key components of the innate immune system. Over the past decade, elegant studies of infection and experimental inflammation have demonstrated the generation of an adoptively transferable, innate immune memory.
In their research perspective, Ding-Wen Chen, Eric K. Wafula, and Peter Kurre from the Department of Pediatrics, Comprehensive Bone Marrow Failure Center, Division of Hematology and the Department of Biomedical and Health Informatics at the Children’s Hospital of Philadelphia, and the Perelman School of Medicine at the University of Pennsylvania, discuss recent findings from their lab on the active role of HSPCs in AML and its potential implications.
“Considering the abundant evidence for AML associated inflammation, and the involvement of healthy HSPCs discussed in our study, the question arises whether sterile cancer-associated inflammation also has long-term functional consequences.”
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About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Oncotarget is indexed and archived byPubMed/Medline,PubMed Central,Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
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