Research Papers:
Paf15 expression correlates with rectal cancer prognosis, cell proliferation and radiation response
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Abstract
Rong Yan1,2, Kun Zhu1, Chengxue Dang1, Ke Lan1, Haonan Wang1, Dawei Yuan1, Wei Chen1, Stephen J. Meltzer2, Kang Li1
1Department of Surgical Oncology, The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi, China
2Departments of Medicine (GI Division) and Oncology, Johns Hopkins School of Medicine and Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
Correspondence to:
Kang Li, email: [email protected]
Stephen J. Meltzer, email: [email protected]
Keywords: Paf15, rectal cancer, prognostic factor, gamma radiation, cell cycle
Received: January 10, 2016 Accepted: April 26, 2016 Published: May 26, 2016
ABSTRACT
Paf15, which participates in DNA repair, is overexpressed in numerous solid tumors. Blocking of Paf15 inhibits the growth of many types of cancer cells; while simultaneously enhancing cellular sensitivity to UV radiation. However, its expression and function in rectal cancer (RC) remain unknown. The current study was undertaken to assess the association of Paf15 expression with RC prognosis, as well as to explore the participation of Paf15 in the response of RC cells to irradiation. Increased Paf15 expression was observed in RC tissues and associated with pTNM stage and poor survival. In vitro, Paf15 induced increased RC cell proliferation while accelerating cell cycle progression, inhibiting cell death, and protecting against gamma radiation-induced DNA damage in RC cells. In conclusion, increased Paf15 expression is associated with increased RC proliferation, decreased patient survival, and a worse radiotherapeutic response.
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