Oncotarget

Research Papers:

Efficient role of IgH 3' regulatory region deficient B-cells in the development of oil granulomas

Nour Ghazzaui _, Alexis Saintamand, Hussein Issaoui, Faten Saad and Yves Denizot

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Oncotarget. 2016; 7:38741-38749. https://doi.org/10.18632/oncotarget.9588

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Abstract

Nour Ghazzaui1, Alexis Saintamand1, Hussein Issaoui1, Faten Saad1, Yves Denizot1

1Department of Immunology, CNRS UMR 7276, CRIBL, Université de Limoges, Limoges, France

Correspondence to:

Yves Denizot, email: [email protected]

Keywords: IgH 3′ regulatory region, knock-out mice, pristine, granulomas

Received: March 25, 2016    Accepted: April 29, 2016    Published: May 25, 2016

ABSTRACT

Functional B-cells are essential for the formation of oil granulomas. The IgH 3′ regulatory region (3′RR) activates important check-points during B-cell maturation. We investigated if 3′RR-deficient B-cells remain efficient to develop oil granulomas in response to pristine. B-cells expressing an IgH 3′RR-deficient allele were similarly recruited to wild type allele expressing B-cells in the granuloma. No differences were observed between 3′RR-deficient mice and control mice for granuloma numbers, cellular composition and ability to express mRNA transcripts for several pro- and anti-inflammatory cytokines. Altogether these results suggest a normal role for 3′RR-deficient B-cells in the development of an acute B-cell-mediated inflammatory response.


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