Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A

Key-Hwan Lim; Jong-Ho Choi; Jung-Hyun Park; Hyeon-Ju Cho; Jang-Joon Park; Eung-Ji Lee; Lan Li; Young-Kil Choi; Kwang-Hyun Baek

doi:10.18632/oncotarget.8976

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Research Papers:

Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A

Key-Hwan Lim _, Jong-Ho Choi, Jung-Hyun Park, Hyeon-Ju Cho, Jang-Joon Park, Eung-Ji Lee, Lan Li, Young-Kil Choi and Kwang-Hyun Baek

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Oncotarget. 2016; 7:34759-34772. https://doi.org/10.18632/oncotarget.8976

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Abstract

Key-Hwan Lim1, Jong-Ho Choi2, Jung-Hyun Park1, Hyeon-Ju Cho1, Jang-Joon Park1, Eung-Ji Lee1, Lan Li1, Young-Kil Choi2,3, Kwang-Hyun Baek1,2

1Department of Biomedical Science, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea

2Department of Internal Medicine, College of Medicine, Bundang CHA Hospital, Bundang-Gu, Seongnam-Si, Gyeonggi-Do 463-400, Republic of Korea

3Department of Internal Medicine, CHA University, CHA General Hospital, Nonhyon-ro, Grangnam-Gu, Seoul 135-081, Republic of Korea

Correspondence to:

Kwang-Hyun Baek, e-mail: [email protected]

Keywords: adipogenesis, CORO2A, deubiquitinating enzyme, USP19

Received: November 09, 2015 Accepted: March 28, 2016 Published: April 25, 2016

ABSTRACT

Deubiquitination via deubiquitinating enzymes (DUBs) has been emerged as one of the important post-translational modifications, resulting in the regulation of numerous target proteins. In this study, we screened new protein biomarkers for adipogenesis, and related studies showed that ubiquitin specific protease 19 (USP19) as a DUB is gradually decreased during adipogenesis and it regulates coronin 2A (CORO2A) as one of the components for the nuclear receptor co-repressor (NCoR) complex in some studies. The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis.

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Research Papers:

Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A

Abstract