Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1

Fushan Shi; Yang Yang; Mohammed Kouadir; Wei Xu; Songhua Hu; Tiancheng Wang

doi:10.18632/oncotarget.8872

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1

Fushan Shi _, Yang Yang, Mohammed Kouadir, Wei Xu, Songhua Hu and Tiancheng Wang

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:30575-30584. https://doi.org/10.18632/oncotarget.8872

Metrics: PDF 2033 views | HTML 2513 views | ?

Abstract

Fushan Shi1,*, Yang Yang 2,*, Mohammed Kouadir3, Wei Xu4, Songhua Hu4, Tiancheng Wang4

1Zhejiang Provincial Key Laboratory of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

2College of Animal Science and Technology, Zhejiang A&F University, Lin’an 311300, China

3Trustchem Co., Ltd., Nanjing 210029, China

4Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China

*These authors contributed equally to this work

Correspondence to:

Fushan Shi, email: [email protected]

Keywords: colitis, inflammation, Blimp-1, NLRP12, TLR4

Received: January 21, 2016 Accepted: March 31, 2016 Published: April 20, 2016

ABSTRACT

NLRP12 is a member of the Nod-like receptor (NLR). Previous studies have reported enhanced colitis-associated inflammatory responses in NLRP12-deficient mice. In this study, we sought to investigate the role of NLRP12 in DSS-stimulated proinflammatory response in dendritic cells and mice colitis, and the molecular mechanisms involved in the development of the inflammation. Our results showed that down-regulation of NLRP12 is required for DSS-induced release of proinflammatory cytokines IL-1β and TNF-α; that PR domain zinc finger protein 1 (also known as Blimp-1) induces NLRP12 down-regulation during DSS-induced proinflammatory response and colitis; and that TLR4 is implicated in the up-regulation of Blimp-1 that led to the down-regulation of NLRP12 expression in DSS-induced colitis. Taken together, the results suggest that the TLR4-Blimp-1 axis promotes DSS induced experimental colitis through the down-regulation of NLRP12.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 8872

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1

Abstract