Oncotarget

Research Papers: Pathology:

Effect of CTLA-4 gene polymorphisms on long-term kidney allograft function in Han Chinese recipients

Yifeng Guo, Junwei Gao, Shuai Gao, Minghua Shang and Fang Guo _

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Oncotarget. 2016; 7:23088-23095. https://doi.org/10.18632/oncotarget.8714

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Abstract

Yifeng Guo1,*, Junwei Gao2,*, Shuai Gao1,*, Minghua Shang3,* and Fang Guo4

1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

3 Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

4 Key Laboratory of Systems Biomedicine (Ministry of Education) and Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China

* These authors have contributed equally to this work

Correspondence to:

Yifeng Guo, email:

Fang Guo, email:

Keywords: kidney transplant, long-term allograft function, estimated glomerular filtration rate, cytotoxic T lymphocyte associated antigen-4, gene polymorphism, Pathology Section

Received: October 22, 2015 Accepted: March 28, 2016 Published: April 12, 2016

Abstract

Single nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte associated antigen-4 gene (CTLA-4) have been associated with graft rejection and long-term clinical outcome after organ transplantation. Our aim was to examine the association between CTLA-4 SNPs (rs733618, rs4553808, rs5742909, rs231775, rs3087243) and long-term allograft function in Chinese renal transplant recipients. Genotyping of CTLA-4 SNPs was performed in 292 renal transplantation recipients. To assess long-term allograft function, the estimated glomerular filtration rate (eGFR) was determined 1, 3, 6, 12, 24, 36, 48 and 60 months after renal transplantation. CTLA-4 rs733618 and rs3087243 alleles and genotypes as well as the rs5742909 and rs231775 genotypes were significantly associated with long-term allograft function after transplantation (P<0.05). Patients with favorable genotypes had higher allograft function during the 60 months after transplantation. The TACGG, CACAG and CGTAA haplotypes were also associated with long-term kidney function after renal transplantation (P<0.05 or P<0.01). In sum, the favorable CTLA-4 rs5742909TT genotype, CTLA-4 rs733618C and rs3087243A alleles, and CACAG and CGTAA haplotypes, as well as the unfavorable rs733618TT, rs3087243GG and rs231775GG genotypes and TACGG haplotype could potentially serve as effective indicators of long-term allograft function in Chinese renal transplantation recipients.


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