Research Papers:
Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer
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Abstract
Huijun Xie1,2,3,*, Xiaoli Ren1,2,3,*, Sainan Xin1,2,3,*, Xiaoliang Lan4, Guifeng Lu1,2,3, Yuan Lin1,2,3, Shaoshan Yang1,2,3, Zhicheng Zeng1,2,3, Wenting Liao1,2,3, Yan-Qing Ding1,2,3, Li Liang1,2,3
1Department of Pathology, Nanfang Hospital, Guangzhou, Guangdong, China
2Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
3Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, Guangdong, China
4Department of General Surgery, Nanfang Hospital, Guangzhou, Guangdong, China
*These authors contributed equally to this work
Correspondence to:
Li Liang, email: [email protected]
Yan-Qing Ding, email: [email protected]
Keywords: hsa_circ_001569, miR-145, colorectal cancer, FMNL2, BAG4
Received: December 08, 2015 Accepted: March 07, 2016 Published: April 05, 2016
ABSTRACT
Circular RNAs (circRNAs), a large class of RNAs, have recently shown huge capabilities as gene regulators in mammals. Some of them bind with microRNAs (miRNAs) and act as natural miRNA sponges to inhibit related miRNAs’ activities. Here we showed that hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. In CRC tissues, circ_001569 negatively correlated with miR-145, and miR-145 correlated negatively with E2F5, BAG4 and FMNL2 expressions. Our study reveals a novel regulatory mechanism of circ_001569 in cell proliferation and invasion in CRC, provides a comprehensive landscape of circ_001569 that will facilitate further biomarker discoveries in the progression of CRC.

PII: 8589