Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism

Lili Sun; Haibo Dong; Zhenchao Zhang; Jie Liu; Yun Hu; Yingdong Ni; Roland Grossmann; Ruqian Zhao

doi:10.18632/oncotarget.8490

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism

Lili Sun _, Haibo Dong, Zhenchao Zhang, Jie Liu, Yun Hu, Yingdong Ni, Roland Grossmann and Ruqian Zhao

PDF | HTML | How to cite

Oncotarget. 2016; 7:27627-27640. https://doi.org/10.18632/oncotarget.8490

Metrics: PDF 1762 views | HTML 2205 views | ?

Abstract

Lili Sun1, Haibo Dong1, Zhenchao Zhang2, Jie Liu1, Yun Hu1, Yingdong Ni1, Roland Grossmann3, Ruqian Zhao1

1Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China

2Department of Veterinary Parasitic Disease, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

3Department of Functional Genomics and Bioregulation, Institute of Animal Genetics, FLI, Mariensee, Neustadt a Rbg, Germany

Correspondence to:

Yingdong Ni, e-mail: [email protected]

Keywords: cell proliferation, cholesterol, coccidial infection, small intestine, miRNAs

Received: December 04, 2015 Accepted: March 18, 2016 Published: March 30, 2016

ABSTRACT

Cell proliferation in the intestine is commonly occurred during infection and inflammation to replace damaged enterocytes, and cholesterol as an essential constituent of cell membrane, is required for cell proliferation and growth. Here we found that coccidium-challenged (CC) chickens showed severe damages in intestinal structure, a significant increase of cell proliferation, and an activation of genes expression involved in the innate immune response. Compared to control (CON), CC chickens showed a marked decrease of cholesterol (Tch) level in the circulating system, but a significant increase in local duodenum epithelium. Increase of LDLR protein combined with a significant decrease of CYP27A1 protein expression in duodenum epithelium may contribute to intestinal cholesterol accumulation in CC chickens. Moreover, we found miRNAs targeting to CYP27A1 gene participating in post-transcriptional regulation. Hence, these results provide a new insight for the intervention of epithelial proliferation and cholesterol metabolism in the gastrointestinal tracts.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 8490

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Activation of epithelial proliferation induced by Eimeria acervulina infection in the duodenum may be associated with cholesterol metabolism

Abstract