Oncotarget

Research Papers:

A novel scoring system predicts adjuvant chemolipiodolization benefit for hepatocellular carcinoma patients after hepatectomy

Li-feng Huang, Xianglei Xing, Dong Wu, Yong Xia, Jun Li, Kui Wang, Zhen-lin Yan, Xu-ying Wan, Le-hua Shi, Tian Yang, Wan Yee Lau, Meng-chao Wu and Feng Shen _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2016; 7:25493-25506. https://doi.org/10.18632/oncotarget.8333

Metrics: PDF 1716 views  |   HTML 2239 views  |   ?  


Abstract

Li-feng Huang1,*, Xianglei Xing1,*, Dong Wu2,*, Yong Xia1, Jun Li1, Kui Wang3, Zhen-lin Yan1, Xu-ying Wan4, Le-hua Shi1, Tian Yang1, Wan Yee Lau1,5, Meng-chao Wu1,4, Feng Shen1

1Department of Hepatic Surgery IV, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

2Department of Hepatic Surgery I, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

3Department of Hepatic Surgery II, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

4Department of Clinical Database, The Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China

5Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

*These authors contributed equally to this work

Correspondence to:

Feng Shen, email: [email protected]

Keywords: hepatocellular carcinoma, liver resection, adjuvant chemolipiodolization, prognosis, scoring system

Received: November 27, 2015     Accepted: March 07, 2016     Published: March 24, 2016

ABSTRACT

Our aim in this study was to develop a prognostic scoring system with which to identify patients most likely to benefit from adjuvant chemolipiodolization (ACL) after liver resection for hepatocellular carcinoma (HCC). Data from 1150 HCC patients who underwent liver resection between 2002 and 2008 at the Eastern Hepatobiliary Surgery Hospital were used to develop the scoring system. Patients were stratified into prognostic subgroups using the new scoring system, and the outcomes of patients who received ACL and those who did not were compared in each subgroup. Using data from 379 patients operated on between 2008 and 2010 for validation, the scoring system had a concordance index (C-index) of 0.75 for predicting post-resectional overall survival (OS). It optimally stratified patients into three prognostic subgroups with scores of 0–5, 6–9 and ≥ 10, having better, medium and worse survival outcomes, respectively. A difference in OS between ACL and non-ACL patients was only detected in the subgroup with scores ≥ 10 (1-, 3-, and 5-year OS rates: 63.9%, 22.6%, and 9.0% vs. 33.8%, 5.6%, and 2.8%, p = 0.001). Our proposed scoring system provides an effective tool for selecting the patients most likely to benefit from ACL.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 8333