Oncotarget

Clinical Research Papers:

Decreased MALL expression negatively impacts colorectal cancer patient survival

Xiaoliang Wang, Junwei Fan, Fudong Yu, Feifei Cui, Xing Sun, Lin Zhong, Dongwang Yan, Chongzhi Zhou, Guilong Deng, Bin Wang, Xiaosheng Qi, Shuyun Wang, Lei Qu, Biao Deng, Ming Pan, Jian Chen, Yupeng Wang, Guohe Song, Huamei Tang, Zongguang Zhou and Zhihai Peng _

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Oncotarget. 2016; 7:22911-22927. https://doi.org/10.18632/oncotarget.8094

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Abstract

Xiaoliang Wang1,*, Junwei Fan1,*, Fudong Yu1,*, Feifei Cui1, Xing Sun1, Lin Zhong1, Dongwang Yan1, Chongzhi Zhou1, Guilong Deng1, Bin Wang1, Xiaosheng Qi1, Shuyun Wang1, Lei Qu1, Biao Deng1, Ming Pan1, Jian Chen1, Yupeng Wang1, Guohe Song1, Huamei Tang2, Zongguang Zhou3 and Zhihai Peng1

1 Department of General Surgery, Shanghai First People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China

2 Department of Pathology, Shanghai First People’s Hospital, Medical College, Shanghai Jiao Tong University, Shanghai, China

3 Department of Gastrointestinal Surgery, Laboratory of Digestive Surgery of State Key Laboratory of Biotherapy, West China hospital, Sichuan University, Guo Xue Xiang, Chengdu, Sichuan China

* These authors have contributed equally to this work

Correspondence to:

Zhihai Peng, email:

Zongguang Zhou, email:

Keywords: biomarker; colorectal cancer; migration; survival

Received: February 09, 2015 Accepted: February 25, 2016 Published: March 15, 2016

Abstract

The aim of the present study was to determine whether MALL expression is associated with colon cancer progression and patient survival. MALL mRNA expression was reduced in the tumor tissues of 70% of the colon cancer patients and 75% of the rectal cancer patients as compared to their normal tissues. MALL protein was also significantly reduced in the tumor tissues of colon cancer patients (P < 0.001). Increased LOH and methylation of MALL was observed in tumor tissues as compared to normal tissues. Reduced MALL expression was associated with vessin invasion, disease recurrence and metastasis or death (P ≤ 0.027). Furthermore, patients with MALL-negative tumors had significantly decreased overall survival (OS) and disease-free survival (DFS) (P < 0.008 and P < 0.011, respectively). Univariate analysis indicated that MALL expression was significantly associated with OS and DFS. Finally, overexpression of MALL suppressed HCT116 and SW480 cell proliferation and inhibited HCT116 migration. MALL may play a role in colorectal cancer progression as suppression of its expression in tumor tissues negatively impacts colorectal cancer patient survival. Further analyses are required to determine if reduced MALL expression is due to LOH and/or methylation.


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