Autophagy: a decisive process for stemness

Laura García-Prat; Marta Martínez-Vicente; Pura Muñoz-Cánoves

doi:10.18632/oncotarget.7766

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Reviews: Autophagy and Cell Death:

Autophagy: a decisive process for stemness

Laura García-Prat, Marta Martínez-Vicente _ and Pura Muñoz-Cánoves

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Oncotarget. 2016; 7:12286-12288. https://doi.org/10.18632/oncotarget.7766

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Abstract

Laura García-Prat1, Marta Martínez-Vicente2,* and Pura Muñoz-Cánoves1,3,*

1 Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain

2 Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute-CIBERNED, Barcelona, Spain

3 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

* These authors have contributted equally to this work

Correspondence to:

Marta Martínez-Vicente, email: marta.martinez@vhir.org

Pura Muñoz-Cánoves, email: pura.munoz@upf.edu

Keywords: autophagy, stem cells, aging, muscle, senescence

Received: January 20, 2016 Accepted: February 16, 2016 Published: February 26, 2016

Abstract

Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective “clean-up” system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.

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Reviews: Autophagy and Cell Death:

Autophagy: a decisive process for stemness

Abstract