Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation

Changping Wu; Xiao Zheng; Xiaodong Li; Andrew Fesler; Wenwei Hu; Lujun Chen; Bin Xu; Qi Wang; Anthony Tong; Stephanie Burke; Jingfang Ju; Jingting Jiang

doi:10.18632/oncotarget.7392

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Research Papers:

Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation

Changping Wu _, Xiao Zheng, Xiaodong Li, Andrew Fesler, Wenwei Hu, Lujun Chen, Bin Xu, Qi Wang, Anthony Tong, Stephanie Burke, Jingfang Ju and Jingting Jiang

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Oncotarget. 2016; 7:14522-14536. https://doi.org/10.18632/oncotarget.7392

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Abstract

Changping Wu1,2,3,*, Xiao Zheng2,3,4,*, Xiaodong Li1,2,3,4,*, Andrew Fesler4, Wenwei Hu1,2,3, Lujun Chen2,3, Bin Xu2,3, Qi Wang2,3, Anthony Tong5, Stephanie Burke4, Jingfang Ju4, Jingting Jiang2,3

1Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China

2Department of Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China

3Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou, China

4Translational Research Laboratory, Department of Pathology, Stony Brook University, Stony Brook, NY, USA

5BioGenex Inc., Fremont, CA, USA

*These authors have contributed equally to this work

Correspondence to:

Jingting Jiang, e-mail: [email protected]

Jingfang Ju, e-mail: [email protected]

Keywords: miR-15a, gastric cancer, Bmi-1, survival

Received: June 30, 2015 Accepted: January 12, 2016 Published: February 15, 2016

ABSTRACT

B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays important roles in gastric cancer, but the epigenetic regulatory mechanism by microRNA (miRNA) and the functional significance of Bmi-1 inhibition in gastric cancer remains elusive. In this study, we systematically investigated the functional roles of miRNA mediated Bmi-1 suppression in gastric cancer. Our results show that the expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. Functional studies revealed that ectopic expression of miR-15a decreased Bmi-1 in gastric cancer cell lines with reduced proliferation and tumor invasion. High levels of Bmi-1 in gastric cancer patients are significantly associated with better overall survival (P = 0.024) based on the Kaplan-Meier survival analysis.

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Research Papers:

Reduction of gastric cancer proliferation and invasion by miR-15a mediated suppression of Bmi-1 translation

Abstract