Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasi-homogenous brain tumors

Ki Mun Kang; Bae Kwon Jeong; Hoon Sik Choi; Jin Ho Song; Byung-Do Park; Young Kyung Lim; Hojin Jeong

doi:10.18632/oncotarget.7280

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Research Papers:

Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasi-homogenous brain tumors

Ki Mun Kang, Bae Kwon Jeong, Hoon Sik Choi, Jin Ho Song, Byung-Do Park, Young Kyung Lim and Hojin Jeong _

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Oncotarget. 2016; 7:12662-12671. https://doi.org/10.18632/oncotarget.7280

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Abstract

Ki Mun Kang1,2, Bae Kwon Jeong1,2, Hoon Sik Choi1,2, Jin Ho Song1,2, Byung-Do Park3, Young Kyung Lim4, Hojin Jeong1,2

1Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, Republic of Korea

2Institute of Health Sciences, Gyeongsang National University, Jinju, Republic of Korea

3Department of Radiation Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea

4Proton Therapy Center, National Cancer Center, Goyang, Republic of Korea

Correspondence to:

Hojin Jeong, e-mail: [email protected]

Young Kyung Lim, e-mail: [email protected]

Keywords: radiosurgery, radiotherapy, Monte Carlo, ray tracing, tissue heterogeneity

Received: October 02, 2015 Accepted: January 23, 2016 Published: February 09, 2016

ABSTRACT

This study was aimed to evaluate the effectiveness of Monte Carlo (MC) method in stereotactic radiotherapy for brain tumor. The difference in doses predicted by the conventional Ray-tracing (Ray) and the advanced MC algorithms was comprehensively investigated through the simulations for phantom and patient data, actual measurement of dose distribution, and the retrospective analysis of 77 brain tumors patients. These investigations consistently showed that the MC algorithm overestimated the dose than the Ray algorithm and the MC overestimation was generally increased as decreasing the beams size and increasing the number of beams delivered. These results demonstrated that the advanced MC algorithm would be inaccurate than the conventional Raytracing algorithm when applied to a (quasi-) homogeneous brain tumors. Thus, caution may be needed to apply the MC method to brain radiosurgery or radiotherapy.

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Research Papers:

Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasi-homogenous brain tumors

Abstract