Oncotarget

Research Papers:

Identifying molecular genetic features and oncogenic pathways of clear cell renal cell carcinoma through the anatomical (PADUA) scoring system

Hui Zhu _, Haoyan Chen, Zhiqian Lin, Guohai Shi, Xiaozhu Lin, Zhiyuan Wu, Xia Zhang and Xi Zhang

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Oncotarget. 2016; 7:10006-10014. https://doi.org/10.18632/oncotarget.7129

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Abstract

Hui Zhu1,*, Haoyan Chen2,*, Zhiqian Lin3, Guohai Shi4, Xiaozhu Lin5, Zhiyuan Wu5, Xia Zhang6, Xi Zhang7

1Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

2State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institute for Digestive Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, China

3Department of Radiology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, China

4Department of Urology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

5Department of Radiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China

6Department of Oncology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China

7Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269-3156, USA

*These authors contributed equally to this work

Correspondence to:

Hui Zhu, e-mail: [email protected]

Haoyan Chen, e-mail: [email protected]

Xi Zhang, e-mail: [email protected]

Keywords: renal cell carcinoma, PADUA, gene mutation, miRNA subtypes, oncogenic pathways

Received: August 22, 2015     Accepted: January 19, 2016     Published: February 02, 2016

ABSTRACT

Although the preoperative aspects and dimensions used for the PADUA scoring system were successfully applied in macroscopic clinical practice for renal tumor, the relevant molecular genetic basis remained unclear. To uncover meaningful correlations between the genetic aberrations and radiological features, we enrolled 112 patients with clear cell renal cell carcinoma (ccRCC) whose clinicopathological data, genomics data and CT data were obtained from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA). Overall PADUA score and several radiological features included in the PADUA system were assigned for each ccRCC. Despite having observed no significant association between the gene mutation frequency and the overall PADUA score, correlations between gene mutations and a few radiological features (tumor rim location and tumor size) were identified. A significant association between rim location and miRNA molecular subtypes was also observed. Survival analysis revealed that tumor size > 7 cm was significantly associated with poor survival. In addition, Gene Set Enrichment Analysis (GSEA) on mRNA expression revealed that the high PADUA score was related to numerous cancer-related networks, especially epithelial to mesenchymal transition (EMT) related pathways. This preliminary analysis of ccRCC revealed meaningful correlations between PADUA anatomical features and molecular basis including genomic aberrations and molecular subtypes.


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