Oncotarget

Research Papers:

Antidepressants in association with reducing risk of oral cancer occurrence: a nationwide population-based cohort and nested case-control studies

Chia-Min Chung _, Tzer-Min Kuo, Shang-Lun Chiang, Zhi-Hong Wang, Chung-Chieh Hung, Hsien-Yuan Lane, Chiu-Shong Liu and Ying-Chin Ko

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Oncotarget. 2016; 7:11687-11695. https://doi.org/10.18632/oncotarget.7049

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Abstract

Chia-Min Chung1,2, Tzer-Min Kuo1, Shang-Lun Chiang1,3, Zhi-Hong Wang1, Chung-Chieh Hung2,4, Hsien-Yuan Lane2,4, Chiu-Shong Liu5, Ying-Chin Ko1,2

1Environment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan

2Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

3Department of Health Risk Management, College of Public Health, China Medical University, Taichung, Taiwan

4Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan

5Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan

Correspondence to:

Ying-Chin Ko, e-mail: [email protected]

Keywords: oral cancer, antidepressants, cohort

Received: September 08, 2015    Accepted: January 20, 2016    Published: January 28, 2016

ABSTRACT

Objectives: Several studies suggested that antidepressant use may increase or decrease the risk of cancer occurrence, depending on specific cancer types. The possible carcinogenic effect of antidepressants has received substantial attention; however, evidence remains inconclusive. Here we investigated associations between the use of antidepressants and occurrences of oral cancer (OC).

Methods: Two million samples were randomly collected from the National Health Insurance Research Database in Taiwan, which covers 98% of the total population (23 million). All patients from2000 to 2009 were followed up. We identified 5103 patients newly diagnosed with OC after antidepressants use in addition to 20,412 non-OC matched subjects and 95,452 unmatched non-OC subjects.

Results: In nested case control analysis, factors associating with OC, including age [OR = 1.02; 95% confidence interval (CI) = 1.01–1.03) and male (OR = 5.30; 95% CI = 4.92–5.70) were independently associated with increased risk of OC. Based on the functions of antidepressants, antidepressants treatment medications were further classified to investigate risk of OC. Selective serotonin reuptake inhibitors (OR = 0.61; 95% CI = 0.53–0.70) and tricyclic antidepressants (OR = 0.57; 95% CI = 0.52–0.63) were associated with reduced risk of OC. The risk of developing OC among subjects taking antidepressants was less than 26% [hazard ratio (HR) =0.74; 95% CI = 0.68–0.81] in prospective cohort study. The effect of a cumulative duration and dose was a significantly reduced risk of OC.

Conclusions: The association between antidepressant use and decreasing OC risk were demonstrated by both prospective and nested case–control studies.


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