MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

Lina Cekaite; Peter W. Eide; Guro E. Lind; Rolf I. Skotheim; Ragnhild A. Lothe

doi:10.18632/oncotarget.6390

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

Lina Cekaite _, Peter W. Eide, Guro E. Lind, Rolf I. Skotheim and Ragnhild A. Lothe

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2016; 7:6476-6505. https://doi.org/10.18632/oncotarget.6390

Metrics: PDF 4600 views | HTML 5558 views | ?

Abstract

Lina Cekaite1,2, Peter W. Eide1,2, Guro E. Lind1,2, Rolf I. Skotheim1,2 and Ragnhild A. Lothe1,2

1 Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway

2 K.G.Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway

Correspondence to:

Lina Cekaite, email:

Keywords: biomarker, colorectal neoplasm, miRNA, metastasis, target gene

Received: August 17, 2015 Accepted: November 16, 2015 Published: November 25, 2015

Abstract

Gene expression is in part regulated by microRNAs (miRNAs). This review summarizes the current knowledge of miRNAs in colorectal cancer (CRC); their role as growth regulators, the mechanisms that regulate the miRNAs themselves and the potential of miRNAs as biomarkers. Although thousands of tissue samples and bodily fluids from CRC patients have been investigated for biomarker potential of miRNAs (>160 papers presented in a comprehensive tables), none single miRNA nor miRNA expression signatures are in clinical use for this disease. More than 500 miRNA-target pairs have been identified in CRC and we discuss how these regulatory nodes interconnect and affect signaling pathways in CRC progression.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 6390

Publication Alerts

Oncoscience

Post-Publication Promotion

Reviews:

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer

Abstract