Oncotarget

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Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis

Xiaowen Song, Na Xin, Wei Wang and Chenghai Zhao _

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Oncotarget. 2015; 6:35579-35588. https://doi.org/10.18632/oncotarget.5758

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Abstract

Xiaowen Song1, Na Xin1, Wei Wang1 and Chenghai Zhao1

1 Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China

Correspondence to:

Chenghai Zhao, email:

Keywords: Wnt, β-catenin, Helicobacter Pylori, gastric cancer

Received: June 23, 2015 Accepted: August 26, 2015 Published: September 21, 2015

Abstract

A section of gastric cancers presents nuclear β-catenin accumulation correlated with H. pylori infection. H. pylori stimulate Wnt/β-catenin pathway by activating oncogenic c-Met and epidermal growth factor receptor (EGFR), or by inhibiting tumor suppressor Runx3 and Trefoil factor 1 (TFF1). H. pylori also trigger Wnt/β-catenin pathway by recruiting macrophages. Moreover, Wnt/β-catenin pathway is found involved in H. pylori-induced gastric cancer stem cell generation. Recently, by using gastroids, researchers have further revealed that H. pylori induce gastric epithelial cell proliferation through β-catenin. These findings indicate that Wnt/β-catenin is an oncogenic pathway activated by H. pylori. Therefore, this pathway is a potential therapy target for H. pylori-related gastric cancer.


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