Influence of non-steroidal anti-inflammatory drugs on  Drosophila melanogaster  longevity

Anton Danilov; Mikhail Shaposhnikov; Oksana Shevchenko; Nadezhda Zemskaya; Alex Zhavoronkov; Alexey Moskalev

doi:10.18632/oncotarget.5118

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers: Gerotarget (Focus on Aging):

Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity

Anton Danilov, Mikhail Shaposhnikov, Oksana Shevchenko, Nadezhda Zemskaya, Alex Zhavoronkov and Alexey Moskalev _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:19428-19444. https://doi.org/10.18632/oncotarget.5118

Metrics: PDF 3272 views | HTML 3519 views | ?

Abstract

Anton Danilov1,2, Mikhail Shaposhnikov2,3, Oksana Shevchenko2, Nadezhda Zemskaya2, Alex Zhavoronkov4 and Alexey Moskalev1,2,3,5

1 Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

2 Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia

3 Syktyvkar State University, Syktyvkar, Russia

4 Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia

5 Moscow Institute of Physics and Technology, Dolgoprudny, Russia

Correspondence to:

Alexey Moskalev, email:

Keywords: longevity, anti-inflammatory drugs, Drosophila, lifespan, geroprotector, geotarget

Received: May 27, 2015 Accepted: July 17, 2015 Published: August 07, 2015

Abstract

Most age-related diseases and aging itself are associated with chronic inflammation. Thus pharmacological inhibition of inflammatory processes may be effective antiaging strategy. In this study we demonstrated that treatment of Drosophila melanogaster with 10 non-steroidal anti-inflammatory drugs (NSAIDs: CAY10404, aspirin, APHS, SC-560, NS-398, SC-58125, valeroyl salicylate, trans-resveratrol, valdecoxib, licofelone) leads to extension of lifespan, delays age-dependent decline of locomotor activity and increases stress resistance. The effect of the lifespan increase was associated with decrease of fecundity. Depending on the concentration, NSAIDs demonstrated both anti- and pro-oxidant properties in Drosophila tissues. However, we failed to identify clear correlation between antioxidant properties of NSAIDs and their pro-longevity effects. The lifespan extending effects of APHS, SC-58125, valeroyl salicylate, trans-resveratrol, valdecoxib, and licofelone were more pronounced in males, valdecoxib and aspirin - in females. We demonstrated that lifespan extension effect of NSAIDs was abolished in flies with defective genes involved in Pkh2-ypk1-lem3-tat2 pathway.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 5118

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers: Gerotarget (Focus on Aging):

Influence of non-steroidal anti-inflammatory drugs on Drosophila melanogaster longevity

Abstract