AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma

Yiran Li; Yuanhui Jia; Qi Che; Qian Zhou; Kai Wang; Xiao-Ping Wan

doi:10.18632/oncotarget.4708

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

This article has been corrected. Correction in: Oncotarget. 2020; 11:755-757.

AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma

Yiran Li, Yuanhui Jia, Qi Che, Qian Zhou, Kai Wang _ and Xiao-Ping Wan

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:26373-26387. https://doi.org/10.18632/oncotarget.4708

Metrics: PDF 2899 views | HTML 2898 views | ?

Abstract

Yiran Li1, Yuanhui Jia2, Qi Che2, Qian Zhou2, Kai Wang2, Xiao-Ping Wan3

1Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China

2Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

3Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China

Correspondence to:

Kai Wang, e-mail: [email protected]

Xiao-Ping Wan, e-mail: [email protected]

Keywords: endometrial carcinoma, Autocrine Motility Factor (AMF)/PhosphoGlucose Isomerase (PGI), MAPK signaling pathway, invasion, prognosis

Received: April 29, 2015 Accepted: July 08, 2015 Published: July 20, 2015

ABSTRACT

Autocrine motility factor (AMF), which is also known as phosphoglucose isomerase (PGI), enhances tumor cell growth and motility. In this study, we found that AMF and its receptor were both highly expressed in Endometrial Carcinoma (EC) tissues compared to normal tissues. Levels of AMF were increased in serum of endometrial cancer patients. Downregulation of AMF by shRNA inhibited invasion, migration and proliferation as well as growth in a three-dimensional culture. AMF cytokine function, but not enzymatic activity of PGI, regulated tumorigenic activities of AMF. The MAPK-ERK1/2 pathway contributed to AMF-induced effects in EC cells. In agreement, Mek inhibitor decreased AMF-induced invasion, migration and proliferation of EC cells. In addition, in two mouse tumor metastasis models (EC cells delivered through left ventricle or intraperitoneally) AMF-silenced EC cells showed decreased tumor proliferative and metastatic capacities. We suggest that AMF/PGI is a potential therapeutic target in endometrial carcinoma.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 4708

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma

Abstract