PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

Chao Li; Xiaoyan Zhou; Jianhui Chen; Yilu Lu; Qianqian Sun; Dachang Tao; Wei Hu; Xulei Zheng; Shasha Bian; Yunqiang Liu; Yongxin Ma

doi:10.18632/oncotarget.4533

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Research Papers:

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

Chao Li, Xiaoyan Zhou, Jianhui Chen, Yilu Lu, Qianqian Sun, Dachang Tao, Wei Hu, Xulei Zheng, Shasha Bian, Yunqiang Liu and Yongxin Ma _

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Oncotarget. 2015; 6:27794-27804. https://doi.org/10.18632/oncotarget.4533

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Abstract

Chao Li1,*, Xiaoyan Zhou1,*, Jianhui Chen1,*, Yilu Lu1, Qianqian Sun1, Dachang Tao1, Wei Hu1, Xulei Zheng1, Shasha Bian1, Yunqiang Liu1, Yongxin Ma1

1Department of Medical Genetics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China

*These authors have contributed equally to this work

Correspondence to:

Yongxin Ma, e-mail: [email protected]

Keywords: PIWIL1, STMN1, tubulin, proliferation, migration

Received: March 04, 2015 Accepted: July 03, 2015 Published: July 15, 2015

ABSTRACT

Human PIWIL1, alias HIWI, is a member of Piwi protein family and expressed in various tumors. However, the underlying mechanism of PIWIL1 in tumorigenesis remains largely unknown. Stathmin1 is a cytosolic phosphoprotein which has a critical role in regulating microtubule dynamics and is overexpressed in many cancers. Here we report that PIWIL1 can directly bind to Stathmin1. Meanwhile, PIWIL1 can up-regulate the expression of Stathmin1 through inhibiting ubiquitin-mediated degradation induced by an E3 ubiquitin ligase RLIM. Furthermore, PIWIL1 can also reduce phosphorylation level of Stathmin1 at Ser-16 through inhibiting the interaction between CaMKII and Stathmin1. Our results showed that PIWIL1 suppresses microtubule polymerization, and promotes cell proliferation and migration via Stathmin1 for the first time. Our study reveals a novel mechanism for PIWIL1 in tumorigenesis.

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Research Papers:

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

Abstract