Research Papers:
Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
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Abstract
Niu Zhanfeng1,2, Li Yanhui3, Fei Zhou2, Hao Shaocai1, Li Guangxing1, Xia Hechun1,4
1Department of Neurosurgery, The General Hospital of Ningxia Medical University, Yinchuan, China
2Department of Neurosurgery, The Xijing Hospital of The Fourth Miltary Medical University, Xi'an, China
3Graduate School of Ningxia Medical University, Yinchuan, China
4Incubation Base of National Key Laboratory for Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, China
Correspondence to:
Xia Hechun, e-mail: [email protected]
Keywords: Per1, Per2, glioma, radiotherapeutic sensitivity
Received: September 24, 2014 Accepted: January 23, 2015 Published: February 07, 2015
ABSTRACT
Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.
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