Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

Seiichiro Ishihara; Motoaki Yasuda; Akihiro Ishizu; Masayori Ishikawa; Hiroki Shirato; Hisashi Haga

doi:10.18632/oncotarget.2912

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Priority Research Papers:

Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

Seiichiro Ishihara _, Motoaki Yasuda, Akihiro Ishizu, Masayori Ishikawa, Hiroki Shirato and Hisashi Haga

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2015; 6:4602-4614. https://doi.org/10.18632/oncotarget.2912

Metrics: PDF 3096 views | HTML 3962 views | ?

Abstract

Seiichiro Ishihara1,2, Motoaki Yasuda3, Akihiro Ishizu4, Masayori Ishikawa5, Hiroki Shirato6, Hisashi Haga1,2

1Faculty of Advanced Life Science, Hokkaido University, Kita-ku, Sapporo 060–0810, Japan

2Research Center for Cooperative Projects, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo 060–8638, Japan

3Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Kita-ku, Sapporo 060–8586, Japan

4Division of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-ku, Sapporo 060–0812, Japan

5Department of Medical Physics, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo 060–8638, Japan

6Department of Radiology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo 060–8638, Japan

Correspondence to:

Hisashi Haga, e-mail: [email protected]

Keywords: Activating transcription factor 5, radioresistance, cell growth, cell invasion, cancer cells

Received: November 04, 2014 Accepted: December 11, 2014 Published: February 17, 2015

ABSTRACT

Radiotherapy is effective for treating various types of tumors. However, some cancer cells survive after irradiation and repopulate tumors with highly malignant phenotypes that correlate with poor prognosis. It is not known how cancer cells survive and generate malignant tumors after irradiation. Here, we show that activating transcription factor 5 (ATF5) promotes radioresistance and malignancy in cancer cells after irradiation. In the G1-S phase of the cell cycle, cancer cells express high levels of ATF5, which promotes cell cycle progression and thereby increases radioresistance. Furthermore, ATF5 increases malignant phenotypes, such as cell growth and invasiveness, in cancer cells in vitro and in vivo. We have identified a new mechanism for the regeneration of highly malignant tumors after irradiation and shown that ATF5 plays a key role in the process.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 2912

Publication Alerts

Post-Publication Promotion

Publication Discount

Priority Research Papers:

Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

Abstract