Precision Oncology:
Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients
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Abstract
Wafik S. El-Deiry1,2, Catherine Bresson1, Fanny Wunder1, Benedito A. Carneiro2, Don S. Dizon2, Jeremy L. Warner2, Stephanie L. Graff2, Christopher G. Azzoli2, Eric T. Wong2, Liang Cheng2, Sendurai A. Mani2, Howard P. Safran2, Casey Williams3, Tobias Meissner3, Benjamin Solomon3, Eitan Rubin4, Angel Porgador4, Guy Berchem5,6,7, Pierre Saintigny8,9, Amir Onn10, Jair Bar10,11, Raanan Berger10, Manon Gantenbein7, Zhen Chen12, Cristiano de Pádua Souza13, Rui Manuel Vieira Reis13,14, Marina Sekacheva15, Andrés Cervantes16, William L. Dahut17, Christina M. Annunziata17, Kerri Gober17, Khaled M. Musallam18, Humaid O. Al-Shamsi18, Ibrahim Abu-Gheida18, Ramon Salazar19, Sewanti Limaye20, Adel T. Aref21, Roger R. Reddel21, Mohammed Ussama Al Homsi22, Abdul Rouf22, Said Dermime22, Jassim Al Suwaidi22, Catalin Vlad23, Rares Buiga23, Amal Al Omari24, Hikmat Abdel-Razeq24, Luis F. Oñate-Ocaña25, Finn Cilius Nielsen26, Leah Graham27, Jens Rueter27, Anthony M. Joshua28,29, Eugenia Girda30, Steven Libutti30, Gregory Riedlinger30, Mohammed E. Salem31, Carol J. Farhangfar31, Ruben A. Mesa31, Bishoy M. Faltas32, Olivier Elemento32, C.S. Pramesh33, Manju Sengar33, Satoru Aoyama34, Sadakatsu Ikeda34, Ioana Berindan-Neagoe35,36, Himabindu Gaddipati37, Mandar Kulkarni37, Elisabeth Auzias38, Maria Gerogianni38, Nicolas Wolikow38, Simon Istolainen38, Pessie Schlafrig39, Naftali Z. Frankel39, Amanda R. Ferraro40, Jim Palma41, Alejandro Piris Gimenez42, Alberto Hernando-Calvo42, Enriqueta Felip42, Apostolia M. Tsimberidou43, Roy S. Herbst44, Josep Tabernero42, Richard L. Schilsky45, Jia Liu21,28,29, Yves Lussier1,46, Jacques Raynaud1, Gerald Batist47, Shai Magidi1 and Razelle Kurzrock1,48
1 Worldwide Innovative Network (WIN) Association – WIN Consortium, Chevilly-Larue, France
2 Legorreta Cancer Center at Brown University, Providence, RI 02912, USA
3 Avera Cancer Institute, Sioux Falls, SD 57105, USA
4 Ben-Gurion University of the Negev, Be'er Sheva, Israel
5 Centre Hospitalier du Luxembourg, Luxembourg
6 University of Luxembourg, Esch-sur-Alzette, Luxembourg
7 Luxembourg Institute of Health, Luxembourg
8 Department of Medical Oncology, Centre Léon Bérard, Lyon, France
9 University of Lyon, Claude Bernard Lyon 1 University, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France
10 Jusidman Cancer Center, Sheba Medical Center, Ramat Gan, Israel
11 Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel
12 Fudan University Shanghai Cancer Center, Shanghai, China
13 Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil
14 Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal
15 I.M Sechenov First Medical State University, Moscow, Russian Federation
16 INCLIVA Instituto de Investigación Sanitaria, Valencia, Spain
17 American Cancer Society, Atlanta, Georgia, MD 21742, USA
18 Burjeel Medical City (BMC), Mohamed Bin Zayed City, Abu Dhabi, UAE
19 Medical Oncology Deparment. Institut Català d'Oncologia. Oncobell Program (IDIBELL), Universitat de Barcelona (Campus Bellvitge), CIBERONC, Barcelona, Spain
20 Sir H.N. Reliance Foundation Hospital and Research Centre, Mumbai, India
21 ProCan, Children’s Medical Research Institute, The University of Sydney, Australia
22 National Center for Cancer Care and Research Hamad Medical Corporation, Doha, Qatar
23 Oncology Institute Ion Chiricuta, Cluj, Romania
24 King Hussein Cancer Center, Amman, Jordan
25 Instituto Nacional de Cancerología (INCan), Mexico City, Mexico
26 Rigshospitalet, Copenhagen, Denmark
27 The Jackson Laboratory, The Maine Cancer Genomics Initiative, Bar Harbor, ME 04609, USA
28 The Kinghorn Cancer Centre, St Vincent’s Hospital, Darlinghurst, Australia
29 School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia
30 Rutgers Cancer Institute, New Brunswick, NJ 08901, USA
31 Wake Forest University Health Sciences/Atrium Health (WFUHS), Winston-Salem, NC 27157, USA
32 Weill Cornell Medical College, NY 10065, USA
33 Tata Memorial Centre, Affiliated to Homi Bhabha National Institute, Mumbai, India
34 Institute of Science Tokyo Hospital, Tokyo, Japan
35 University of Medicine and Pharmacy Iuliu Hatieganu, Cluj, Romania
36 Academy of Medical Sciences, Bucharest, Romania
37 Vyas Cancer Research (VCR Park), Maharanipeta, Visakhpatnam, Andhra Pradesh, India
38 Cure51, Paris, France
39 CHAIM Medical Resource Organization, NY 10950, USA
40 Cancer is an A*, LLC, Manalapan Township, NJ 07726, USA
41 TargetCancer Foundation, Cambridge, MA 02139, USA
42 Vall d’Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain
43 The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA
44 Yale School of Medicine, New Haven, CT 06510, USA
45 The University of Chicago, Chicago, IL 60637, USA
46 The University of Utah, Salt Lake City, UT 84112, USA
47 Segal Cancer Centre, Jewish Hospital, McGill University, Montreal, Quebec, Canada
48 Medical College of Wisconsin, Milwaukee, WI 53226, USA
Correspondence to:
Wafik S. El-Deiry, | email: | wafik@brown.edu |
Keywords: precision oncology; N-of-1 basket trials; AI algorithms; digital pathology; drug access
Received: December 30, 2024 Accepted: February 27, 2025 Published: March 12, 2025
ABSTRACT
The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity—including financial and time—are important goals of modern oncology. The Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine founded by Drs. John Mendelsohn and Thomas Tursz provided a vision for innovation, collaboration and global impact in precision oncology. Through pursuit of transcriptomic signatures, artificial intelligence (AI) algorithms, global precision cancer medicine clinical trials and input from an international Molecular Tumor Board (MTB), WIN has led the way in demonstrating patient benefit from precision-therapeutics through N-of-1 molecularly-driven studies. WIN Next-Generation Precision Oncology (WINGPO) trials are being developed in the neoadjuvant, adjuvant or metastatic settings, incorporate real-world data, digital pathology, and advanced algorithms to guide MTB prioritization of therapy combinations for a diverse global population. WIN has pursued combinations that target multiple drivers/hallmarks of cancer in individual patients. WIN continues to be impactful through collaboration with industry, government, sponsors, funders, academic and community centers, patient advocates, and other stakeholders to tackle challenges including drug access, costs, regulatory barriers, and patient support. WIN’s collaborative next generation of precision oncology trials will guide treatment selection for patients with advanced cancers through MTB and AI algorithms based on serial liquid and tissue biopsies and exploratory omics including transcriptomics, proteomics, metabolomics and functional precision medicine. Our vision is to accelerate the future of precision oncology care.

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