Research Perspectives:
Melatonin and carcinogenesis in mice: the 50th anniversary of relationships
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Abstract
Vladimir N. Anisimov1,* and Alexey G. Golubev1,*
1 Department of Carcinogenesis and Oncogerontology, N.N. Petrov National Medical Research Center of Oncology, Saint Petersburg 197758, Russia
* The authors contributed equally to this work
Correspondence to:
Vladimir N. Anisimov, | email: | [email protected] |
Keywords: cancer; melatonin; mice
Received: November 07, 2023 Accepted: November 16, 2023 Published: December 12, 2023
ABSTRACT
The history of studies of melatonin effects on cancer in mice is outlined, the main lesson being that the systemic in vivo effects of melatonin on animals may overwhelm the in vitro effects found using tissue explants or cell cultures. In particular, the timing of melatonin administration is of crucial importance for using the drug, which is freely available over counter and thus needs no licensing for its applications in oncology.
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PII: 28537