Research Papers:
Serum microRNAs as new criteria for referral to early palliative care services in treatment-naïve advanced cancer patients
PDF | Full Text | Supplementary Files | How to cite | Press Release
Metrics: PDF 655 views | Full Text 1938 views | ?
Abstract
Tomofumi Miura1,2, Shuichi Mitsunaga1,3, Juntaro Matsuzaki4,5, Satoko Takizawa6, Ken Kato7, Atsushi Ochiai8 and Takahiro Ochiya4,9
1 Division of Biomarker Discovery, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan
2 Department of Palliative Medicine, National Cancer Center Hospital East, Kashiwa, Japan
3 Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
4 Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo, Japan
5 Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan
6 Toray Industries, Inc., Kamakura, Japan
7 Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
8 Pathology Division, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Kashiwa, Japan
9 Department of Molecular and Cellular Medicine, Tokyo Medical University, Tokyo, Japan
Correspondence to:
Shuichi Mitsunaga, | email: | [email protected] |
Keywords: microRNA; early palliative care; integration; cancer; referral
Received: August 04, 2022 Accepted: November 23, 2022 Published: December 17, 2022
ABSTRACT
A major obstacle to the implementation of early palliative care (EPC) is the lack of objective criteria for referral to EPC. Circulating microRNAs (miRNAs) have been recognized as promising biomarkers. The present study investigated objective definitions for referral to EPC using microRNA. A total of 178 serum samples were obtained from patients with lung, gastrointestinal, colorectal, bile duct, pancreas and bladder cancers who were treatment-naïve and received chemotherapy between January 2011 and December 2013 at National Cancer Center Hospital East. We investigated expression levels of miRNAs using microarrays. The primary outcome was prediction of admission to a palliative care unit ≤6 months after first visit. Diagnostic models using clinical characteristics, miRNAs and combinations of both were constructed. The miRNA models were constructed using 6 miRNA levels. The best areas under the receiver operating characteristic curve (AUCs) of the clinical model was 0.741, while the average AUCs of miRNA-based models and combination models were 0.769 and 0.806, respectively. Combination models showed higher AUCs than the clinical model (p < 0.023). The present combination models might offer new objective definitions for referral to EPC and thus contribute to real-world implementation of EPC.
![Creative Commons License](/images/80x15.png)
PII: 28327