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Cancer stem cells and macrophages: molecular connections and future perspectives against cancer
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Abstract
Beatrice Aramini1, Valentina Masciale1, Giulia Grisendi2, Federico Banchelli3, Roberto D’Amico3, Antonino Maiorana4, Uliano Morandi1, Massimo Dominici2 and Khawaja Husnain Haider5
1 Division of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
2 Division of Oncology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
3 Center of Statistic, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
4 Institute of Pathology, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy
5 Sulaiman AlRajhi Medical School, AlQaseem, Kingdom of Saudi Arabia
Correspondence to:
Beatrice Aramini, | email: | [email protected] |
Keywords: cancer stem cells; macrophages; future perspectives; cancer; target treatments
Received: May 11, 2020 Accepted: January 07, 2021 Published: February 02, 2021
ABSTRACT
Cancer stem cells (CSCs) have been considered the key drivers of cancer initiation and progression due to their unlimited self-renewal capacity and their ability to induce tumor formation. Macrophages, particularly tumor-associated macrophages (TAMs), establish a tumor microenvironment to protect and induce CSCs development and dissemination. Many studies in the past decade have been performed to understand the molecular mediators of CSCs and TAMs, and several studies have elucidated the complex crosstalk that occurs between these two cell types. The aim of this review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies.
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