Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

Hanieh Montaseri; Cherie Ann Kruger; Heidi Abrahamse

doi:10.18632/oncotarget.27596

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

Hanieh Montaseri, Cherie Ann Kruger and Heidi Abrahamse _

PDF | Full Text | Supplementary Files | How to cite | Press Release

Oncotarget. 2020; 11:2120-2136. https://doi.org/10.18632/oncotarget.27596

Metrics: PDF 2640 views | Full Text 3768 views | ?

Abstract

Hanieh Montaseri1, Cherie Ann Kruger1 and Heidi Abrahamse1

1 Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein 2028, South Africa

Correspondence to:

Heidi Abrahamse,

email:

[email protected]

Keywords: photodynamic therapy; photosensitizers; nanoparticle delivery; targeting agents; breast cancer treatment

Received: March 11, 2020 Accepted: April 27, 2020 Published: June 02, 2020

ABSTRACT

Targeted Photodynamic therapy (TPDT) is a non-invasive and site-specific treatment modality, which has been utilized to eradicate cancer tumour cells with photoactivated chemicals or photosensitizers (PSs), in the presence of laser light irradiation and molecular tissue oxygen. Breast cancer is the commonest cancer among women worldwide and is currently treated using conventional methods such as chemotherapy, radiotherapy and surgery. Despite the recent advancements made in PDT, poor water solubility and non-specificity of PSs, often affect the overall effectivity of this unconventional cancer treatment. With respect to conventional PS obstacles, great strides have been made towards the application of targeted nanoparticles in PDT to resolve these limitations. Therefore, this review provides an overview of scientific peer reviewed published studies in relation to functionalized organic nanoparticles (NPs) for effective TPDT treatment of breast cancer over the last 10 years (2009 to 2019). The main aim of this review is to highlight the importance of organic NP active based PDT targeted drug delivery systems, to improve the overall biodistribution of PSs in breast cancer tumour’s.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 27596

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells

Abstract