Real-world evidence to guide healthcare policies in oncology

Marco Donia; Steen Werner Hansen; Inge Marie Svane

doi:10.18632/oncotarget.27077

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Research Perspectives:

Real-world evidence to guide healthcare policies in oncology

Marco Donia _, Steen Werner Hansen and Inge Marie Svane _

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Oncotarget. 2019; 10:4513-4515. https://doi.org/10.18632/oncotarget.27077

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Abstract

Marco Donia1, Steen Werner Hansen2 and Inge Marie Svane1

1 National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Herlev, Denmark

2 Head Office, Herlev and Gentofte Hospital, Herlev, Denmark

Correspondence to:

Marco Donia,	email:	[email protected]
Inge Marie Svane,	email:	[email protected]

Keywords: real-world evidence; real-world data; clinical trial eligibility

Received: June 02, 2019 Accepted: June 19, 2018 Published: July 16, 2019

ABSTRACT

Randomized controlled clinical trials (RCTs) in oncology enroll patients who meet strict protocol-specified criteria. Many of these criteria overlap across multiple RCTs. A vast proportion of patients with metastatic cancer do not meet such criteria. Hence, patient populations encountered in clinical practice are essentially different from RCT-populations, questioning the representativeness of these trials. A real-world evidence approach, using data from clinical practice, is increasingly employed to complement the information on drug safety and efficacy obtained from traditional clinical trials.

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Research Perspectives:

Real-world evidence to guide healthcare policies in oncology

Abstract