Research Papers:
PARP1-Erk synergism in proliferating cells
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Abstract
Leonid Visochek1 and Malka Cohen-Armon1,2
1Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel Aviv 69978, Israel
2Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv 69978, Israel
Correspondence to:
Malka Cohen-Armon, email: [email protected]
Keywords: PARP1-Erk binding; PARP1-dependent Erk activity; c-Fos; Mouse embryonic fibroblasts
Received: May 27, 2018 Accepted: May 31, 2018 Published: June 26, 2018
ABSTRACT
A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning. It was similarly required for cardiomyocytes development. Here, we identified this mechanism in Erk-induced gene expression promoting proliferation. This mechanism can be targeted in malignant cells.
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