LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice

Eloise Ferreira; Monique J. Bignoux; Tyrone C. Otgaar; Nicolas Tagliatti; Katarina Jovanovic; Boitelo T. Letsolo; Stefan F.T. Weiss

doi:10.18632/oncotarget.25473

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice

Eloise Ferreira, Monique J. Bignoux, Tyrone C. Otgaar, Nicolas Tagliatti, Katarina Jovanovic, Boitelo T. Letsolo and Stefan F.T. Weiss _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2018; 9:27059-27073. https://doi.org/10.18632/oncotarget.25473

Metrics: PDF 1553 views | HTML 2506 views | ?

Abstract

Eloise Ferreira1, Monique J. Bignoux1, Tyrone C. Otgaar1, Nicolas Tagliatti1, Katarina Jovanovic1,2, Boitelo T. Letsolo1 and Stefan F.T. Weiss1

1School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Republic of South Africa

2Present address: UCL Institute of Ophthalmology, London, UK

Correspondence to:

Stefan F.T. Weiss, email: [email protected]

Keywords: Alzheimer’s disease; amyloid beta; LRP-LR; therapeutic antibody; transgenic mice

Received: September 12, 2017 Accepted: May 08, 2018 Published: June 05, 2018

ABSTRACT

Alzheimer’s disease (AD) is a neurodegenerative disease caused by accumulation of amyloid beta (Aβ) plaque and neurofibrillary tangle formation. We have shown in vitro, that knock-down and blockade of the 37 kDa/67 kDa Laminin Receptor (LRP/LR) resulted in reduced Aβ induced cytotoxicity and Aβ accumulation. In order to test the effect of blocking LRP/LR on Aβ formation and AD associated symptoms, AD transgenic mice received the anti-LRP/LR specific antibody, IgG1-iS18 through intranasal administration. We show that this treatment resulted in an improvement in memory, and decreased Aβ plaque formation. Moreover, a significant decrease in Aβ₄₂ protein expression with a concomitant increase in amyloid precursor protein (APP) and telomerase reverse transcriptase (mTERT) levels was observed. These data recommend IgG1-iS18 as a potentially powerful therapeutic antibody for AD treatment.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 25473

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice

Abstract