Oncotarget

Research Papers:

Prostate stem cell antigen mRNA in blood is a predictor of survival after radical prostatectomy in patients with high-risk prostate cancer

Yoon Seok Suh, Jae Young Joung, Sung Han Kim, Jeong Eun Kim, Moon Kyung Choi, Weon Seo Park, Sang-Jin Lee, Ho Kyung Seo, Jinsoo Chung and Kang Hyun Lee _

PDF  |  HTML  |  How to cite

Oncotarget. 2018; 9:26291-26298. https://doi.org/10.18632/oncotarget.25207

Metrics: PDF 1187 views  |   HTML 1582 views  |   ?  


Abstract

Yoon Seok Suh1,*, Jae Young Joung1,*, Sung Han Kim1, Jeong Eun Kim1, Moon Kyung Choi2, Weon Seo Park2, Sang-Jin Lee3, Ho Kyung Seo1, Jinsoo Chung1 and Kang Hyun Lee1

1Department of Urology, Center for Prostate Cancer, Hospital, National Cancer Center, Goyang, Gyeonggi-do, Korea

2Department of Pathology, Center for Prostate Cancer, Hospital, National Cancer Center, Goyang, Gyeonggi-do, Korea

3Immunotherapeutics Branch, Research Institute, National Cancer Center, Goyang, Gyeonggi-do, Korea

*These authors contributed equally to this work

Correspondence to:

Kang Hyun Lee, email: [email protected]

Keywords: prostate stem cell antigen; prostate cancer; biochemical recurrence; survival

Received: September 04, 2017     Accepted: March 13, 2018     Published: May 29, 2018

ABSTRACT

Objectives: To investigate whether the preoperative detection of prostate stem cell antigen (PSCA) mRNA in blood has predictive value for biochemical recurrence, overall survival, and cancer-specific survival after radical prostatectomy in patients with high-risk prostate cancer.

Results: Median age was 67 years (interquartile range: 63-71), and median follow-up was 41 months (interquartile range: 25–65). PSCA mRNA was detected in 151 patients (51.1%). Biochemical recurrence was developed in 101 patients (34.2%), and all-cause mortality and prostate cancer-specific mortality occurred in 17 (5.7%) and 8 (2.7%) patients, respectively. Kaplan–Meier analysis revealed significant differences in biochemical recurrence, overall survival, and cancer-specific survival according to PSCA mRNA positivity. Cox regression hazards model analysis showed that PSCA mRNA positivity was an independent predictor of biochemical recurrence, overall survival, and cancer-specific survival.

Conclusions: PSCA mRNA in the peripheral blood was related to poor prognosis. Detection of PSCA mRNA by polymerase chain reaction in peripheral blood can be used to predict survival after radical prostatectomy in patients with high-risk prostate cancer. Future study with larger cohort and long-term follow-up is required to confirm this finding.

Materials and methods: A total of 295 patients with high-risk prostate cancer scheduled to undergo radical prostatectomy were prospectively enrolled from 2008 to 2016. Nested reverse transcription polymerase chain reaction was used to detect cells with PSCA mRNA in peripheral blood. The predicting ability of PSCA mRNA positivity for biochemical recurrence, overall survival, and cancer-specific survival after radical prostatectomy was evaluated.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 25207