Role of tumor microenvironment in ovarian cancer pathobiology

Alia Ghoneum; Hesham Afify; Ziyan Salih; Michael Kelly; Neveen Said

doi:10.18632/oncotarget.25126

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Role of tumor microenvironment in ovarian cancer pathobiology

Alia Ghoneum, Hesham Afify, Ziyan Salih, Michael Kelly and Neveen Said _

PDF | HTML | How to cite

Oncotarget. 2018; 9:22832-22849. https://doi.org/10.18632/oncotarget.25126

Metrics: PDF 2403 views | HTML 10800 views | ?

Abstract

Alia Ghoneum1, Hesham Afify1, Ziyan Salih2, Michael Kelly3 and Neveen Said1,2,4

1Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA

2Department of Cancer Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA

3Department of Cancer Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA

4Department of Cancer Urology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA

Correspondence to:

Neveen Said, email: [email protected]

Keywords: ovarian cancer; tumor microenvironment; peritoneal metastasis; targeted therapy; resistance and recurrence

Received: July 10, 2017 Accepted: January 21, 2018 Published: April 27, 2018

ABSTRACT

Ovarian cancer is the fifth most common cancer affecting the female population and at present, stands as the most lethal gynecologic malignancy. Poor prognosis and low five-year survival rate are attributed to nonspecific symptoms and below par diagnostic criteria at early phases along with a lack of effective treatment at advanced stages. It is thus of utmost importance to understand ovarian carcinoma through several lenses including its molecular pathogenesis, epidemiology, histological subtypes, hereditary factors, diagnostic approaches and methods of treatment. Above all, it is crucial to dissect the role that the unique peritoneal tumor microenvironment plays in ovarian cancer progression and metastasis. This review seeks to highlight several important aspects of ovarian cancer pathobiology as a means to provide the necessary background to approach ovarian malignancies in the future.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 25126

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Role of tumor microenvironment in ovarian cancer pathobiology

Abstract