Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

Laura Ciarlo; Rosa Vona; Valeria Manganelli; Lucrezia Gambardella; Carla Raggi; Matteo Marconi; Walter Malorni; Maurizio Sorice; Tina Garofalo; Paola Matarrese

doi:10.18632/oncotarget.24792

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

Laura Ciarlo, Rosa Vona, Valeria Manganelli, Lucrezia Gambardella, Carla Raggi, Matteo Marconi, Walter Malorni, Maurizio Sorice, Tina Garofalo and Paola Matarrese _

PDF | HTML | Supplementary Files | How to cite

Oncotarget. 2018; 9:18869-18884. https://doi.org/10.18632/oncotarget.24792

Metrics: PDF 2555 views | HTML 3853 views | ?

Abstract

Laura Ciarlo1,*, Rosa Vona1,*, Valeria Manganelli2,*, Lucrezia Gambardella1, Carla Raggi3, Matteo Marconi1, Walter Malorni1, Maurizio Sorice2, Tina Garofalo2,# and Paola Matarrese1,4,#

1Oncology Unit, Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy

2Department of Experimental Medicine, Sapienza University, Rome, Italy

3Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy

4Center of Metabolomics, Rome, Italy

*These authors contributed equally to this work

#These authors to be considered as Senior Authors

Correspondence to:

Paola Matarrese, email: [email protected]

Keywords: lipid rafts; mitochondria; fusion; apoptosis; reactive oxygen species

Received: July 22, 2017 Accepted: February 27, 2018 Published: April 10, 2018

ABSTRACT

The regulation of the mitochondrial dynamics and the balance between fusion and fission processes are crucial for the health and fate of the cell. Mitochondrial fusion and fission machinery is controlled by key proteins such as mitofusins, OPA-1 and several further molecules. In the present work we investigated the implication of lipid rafts in mitochondrial fusion induced by Mdivi-1. Our results underscore the possible implication of lipid “rafts” in mitochondrial morphogenetic changes and their homeostasis.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24792

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Recruitment of mitofusin 2 into “lipid rafts” drives mitochondria fusion induced by Mdivi-1

Abstract