Comprehensive analysis of telomerase inhibition by gallotannin

Nikita Savelyev; Polina Baykuzina; Svetlana Dokudovskaya; Olga Lavrik; Maria Rubtsova; Olga Dontsova

doi:10.18632/oncotarget.24642

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

Comprehensive analysis of telomerase inhibition by gallotannin

Nikita Savelyev, Polina Baykuzina, Svetlana Dokudovskaya, Olga Lavrik, Maria Rubtsova _ and Olga Dontsova

PDF | HTML | How to cite

Oncotarget. 2018; 9:18712-18719. https://doi.org/10.18632/oncotarget.24642

Metrics: PDF 2316 views | HTML 3284 views | ?

Abstract

Nikita Savelyev1, Polina Baykuzina2, Svetlana Dokudovskaya3, Olga Lavrik4,5, Maria Rubtsova1,6 and Olga Dontsova1,6

1Lomonosov Moscow State University, Department of Chemistry, and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, 119992, Russia

2Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119992, Russia

3UMR 8126, CNRS, University Paris-Sud, Université Paris Saclay, Institut de Cancérologie Gustave-Roussy, 94805, Villejuif, France

4Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

5Novosibirsk State University, Novosibirsk, 630090, Russia

6Skolkovo Institute of Science and Technology, Skolkovo, Moscow region, 143025, Russia

Correspondence to:

Maria Rubtsova, email: [email protected]

Keywords: telomerase; telomere; gallotannin; inhibition; poly(ADP-ribosy)lation

Received: August 18, 2017 Accepted: February 24, 2018 Published: April 10, 2018

ABSTRACT

Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24642

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

Comprehensive analysis of telomerase inhibition by gallotannin

Abstract