TP53  mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [ 18 F] fluorodeoxyglucose ( 18 F-FDG PET)

Geraldine H. Chang; Razelle Kurzrock; Lisa Tran; Maria Schwaederle; Carl K. Hoh

doi:10.18632/oncotarget.24508

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG PET)

Geraldine H. Chang, Razelle Kurzrock, Lisa Tran, Maria Schwaederle and Carl K. Hoh _

PDF | HTML | How to cite

Oncotarget. 2018; 9:14306-14310. https://doi.org/10.18632/oncotarget.24508

Metrics: PDF 1533 views | HTML 2130 views | ?

Abstract

Geraldine H. Chang1, Razelle Kurzrock2, Lisa Tran2, Maria Schwaederle2 and Carl K. Hoh1

1Department of Radiology, Nuclear Medicine UC San Diego Health, San Diego, California, USA

2Center for Personalized Cancer Therapy, UCSD Moores Cancer Center, La Jolla, California, USA

Correspondence to:

Carl K. Hoh, email: [email protected]

Keywords: TP53; personalized cancer therapy; PET/CT; SUVmax

Received: August 31, 2017 Accepted: February 10, 2018 Epub: February 16, 2018 Published: March 06, 2018

ABSTRACT

Background: Our study explored the relationship between the molecular changes in cancer and the maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) with [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG).

Results: A higher SUVmax correlated with TP53 alterations, but not with histologic diagnosis or other gene/pathway mutations or copy number alterations. In data from breast, lung and colon cancer, patients with the highest SUVmax show more genomic anomalies compared to those with the lowest SUVmax (P < 0.005).

Conclusions: A higher SUVmax on ¹⁸F-FDG PET/CT is associated with TP53 tumor suppressor gene anomalies and the presence of more genomic anomalies. Since TP53 alterations and high SUVmax both correlate with a poor prognosis, the underlying mechanism/implications of this association merit further study.

Methods: Overall, 176 patients with diverse cancers had a tumor biopsy within 6 months after a PET/CT image for SUVmax measurement. The biopsy was interrogated by next generation sequencing (182 to 315 genes). TP53, EGFR, ALK, MYC, MET and FGF/FGFR genes and DNA repair, PI3K/Akt/mTOR (PAM), MEK, CYCLIN, and WNT pathway genes were analyzed.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24508

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG PET)

Abstract

Publication Alerts

Post-Publication Promotion

Publication Discount

Research Papers:

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [18F] fluorodeoxyglucose (18F-FDG PET)

Abstract

TP53 mutations and number of alterations correlate with maximum standardized uptake value (SUVmax) determined by positron emission tomography/computed tomography (PET/CT) [¹⁸F] fluorodeoxyglucose (¹⁸F-FDG PET)