Predictive value of inflammation-based prognostic scores in patients with metastatic renal cell carcinoma treated with cytoreductive nephrectomy

Hironori Fukuda; Toshio Takagi; Tsunenori Kondo; Satoru Shimizu; Kazunari Tanabe

doi:10.18632/oncotarget.24507

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Research Papers:

Predictive value of inflammation-based prognostic scores in patients with metastatic renal cell carcinoma treated with cytoreductive nephrectomy

Hironori Fukuda, Toshio Takagi _, Tsunenori Kondo, Satoru Shimizu and Kazunari Tanabe

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Oncotarget. 2018; 9:14296-14305. https://doi.org/10.18632/oncotarget.24507

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Abstract

Hironori Fukuda1, Toshio Takagi1, Tsunenori Kondo2, Satoru Shimizu3 and Kazunari Tanabe1

1Department of Urology, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

2Department of Urology, Tokyo Women’s Medical University Medical Center East, Arakawa-ku, Tokyo, Japan

3Department of Medical Education, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, Japan

Correspondence to:

Toshio Takagi, email: [email protected]

Keywords: renal cell carcinoma; metastasis; cytoreductive nephrectomy; prognosis; inflammation-based prognostic score

Received: July 26, 2017 Accepted: February 10, 2018 Epub: February 16, 2018 Published: March 06, 2018

ABSTRACT

Inflammation-based prognostic scores are useful for predicting survival in various cancers. Here, we aimed to determine the most useful inflammation-based prognostic score for predicting survival in patients with metastatic renal cell carcinoma undergoing cytoreductive nephrectomy. We retrospectively analyzed the data of 152 patients who underwent cytoreductive nephrectomy for metastatic renal cell carcinoma between 1986 and 2015. In the multivariate stepwise analysis, the combination of age, Memorial Sloan-Kettering Cancer Center score, histology, sarcomatoid change, clinical nodal stage, brain metastasis, and liver metastasis was a significant predictor for survival (Harrell's concordance index [c-index]: 0.638). The c-index of the combination improved with the addition of an inflammation-based prognostic score: C-reactive protein (c-index: 0.672), Glasgow prognostic score (c-index: 0.674), neutrophil-to-lymphocyte ratio (c-index: 0.685), lymphocyte-to-monocyte ratio (c-index: 0.670), platelet-to-lymphocyte ratio (c-index: 0.666), systemic inflammation response index (c-index: 0.652), and systemic immune-inflammation index (c-index: 0.678). The neutrophil-to-lymphocyte ratio provided the greatest improvement in the c-index. Additional multivariate analysis showed that the neutrophil-to-lymphocyte ratio was an independent prognostic factor for survival (P < 0.0001). The neutrophil-to-lymphocyte ratio was the most useful inflammation-based prognostic score for predicting survival in patients with metastatic renal cell carcinoma treated with cytoreductive nephrectomy.

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Research Papers:

Predictive value of inflammation-based prognostic scores in patients with metastatic renal cell carcinoma treated with cytoreductive nephrectomy

Abstract