Oncotarget

Research Papers:

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

Hsien-Feng Chang, Po-Jen Hsiao, Yu-Juei Hsu, Fu-Huang Lin, Chin Lin, Wen Su, Hsiang-Cheng Chen and Sui-Lung Su _

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2018; 9:14444-14455. https://doi.org/10.18632/oncotarget.24469

Metrics: PDF 1453 views  |   HTML 2014 views  |   ?  


Abstract

Hsien-Feng Chang1, Po-Jen Hsiao2,3,4, Yu-Juei Hsu2, Fu-Huang Lin1, Chin Lin1, Wen Su5, Hsiang-Cheng Chen6,* and Sui-Lung Su1,*

1School of Public Health, National Defense Medical Center, Taiwan, ROC

2Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC

3Department of Internal Medicine, Taoyuan Armed Forces General Hospital, Taiwan, ROC

4Big Data Research Center, Fu-Jen Catholic University, Taiwan, ROC

5Department of Nursing, Tri-Service General Hospital, Taiwan, ROC

6Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC

*These authors have contributed equally to this work

Correspondence to:

Sui-Lung Su, email: [email protected]

Hsiang-Cheng Chen, email: [email protected]

Keywords: angiotensin II receptor type 1; AGTR1 A1166C; chronic kidney disease; meta-analysis; gene-environment interaction

Received: June 08, 2017    Accepted: February 03, 2018    Epub: February 12, 2018    Published: March 06, 2018

ABSTRACT

Studies of the association between angiotensin II receptor type 1 A1166C (AGTR1 A1166C) polymorphism and chronic kidney disease (CKD) risk have yielded conflicting results. We conducted a combined case-control study and meta-analysis to better define this association. The case-control study included 634 end-stage renal disease (ESRD) patients and 739 healthy controls. AGTR1 A1166C genotype was determined using polymerase chain reaction and iPLEX Gold SNP genotyping methods. The meta-analysis included 24 studies found in the PubMed and Cochrane Library databases. Together, the case-control study and meta-analysis included 36 populations (7,918 cases and 6,905 controls). We found no association between the C allele and ESRD (case-control study: OR: 1.02, 95% CI: 0.77–1.37; meta-analysis: OR: 1.07; 95% CI: 0.97–1.18). Co-dominant, dominant, and recessive model results were also not significant. No known environmental factors moderated the effect of AGTR1 A1166C on CKD in our gene-environment interaction analysis. Sensitivity analysis showed an AGTR1 A1166C-CKD association in Indian populations (OR: 1.46, 95% CI: 1.26–1.69), but not in East Asian or Caucasian populations. Additional South Asian studies will be required to confirm the potential role of this polymorphism in CKD.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 24469