Oncotarget

Clinical Research Papers:

The association between risk of limb fracture and type 2 diabetes mellitus

Jie Liu _, Lei Cao, Yao-Wen Qian, Zhi-Xin Chen, Shi-Fang Guo, Wei-Qiang Sun and Zong-Ru He

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2018; 9:31302-31310. https://doi.org/10.18632/oncotarget.23937

Metrics: PDF 1351 views  |   HTML 1712 views  |   ?  


Abstract

Jie Liu1,*, Lei Cao2,*, Yao-Wen Qian1, Zhi-Xin Chen1, Shi-Fang Guo1, Wei-Qiang Sun3 and Zong-Ru He1

1Orthopaedic Department of People’s Hospital of Gansu Provincial, Lanzhou 730000, China

2Pediatrical Department of Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730000, China

3Traditional Chinese Hospital of Gansu Zhang County, Dingxi 743000, China

*These authors contributed equally to this work

Correspondence to:

Yao-Wen Qian, email: [email protected]

Keywords: limb fracture; diabetes mellitus; risk factor; meta-analysis

Received: October 14, 2017     Accepted: November 02, 2017     Epub: January 05, 2018     Published: July 27, 2018

ABSTRACT

Background: Recently, increasing reports showed that the risk of fracture may be correlated with type 2 diabetes mellitus (T2DM). However, their results still remained controversial. Thus we performed a meta-analysis including 11 studies to estimate the risk factor of limb fracture in type 2 diabetes mellitus.

Materials and Methods: Databases including PubMed, Embase, Cochrane Library and Web of Science were searched to September, 2017. Risk Ratio (RR) with its 95% confidence intervals (CI) was used to evaluate the association between risk of limb fracture and type 2 diabetes mellitus. Two reviewers assessed the quality of all the included studies and extracted data for analysis independently.

Results: A total of 11 studies including 663,923 participants were included in this meta-analysis. Our analysis results showed that patients with type 2 diabetes mellitus had a significant association with risk of limb fracture (RR 1.18; 95% CI 1.02–1.35), including leg or ankle fracture (RR 1.80; 95% CI 1.13–2.87). Subgroup analysis showed individuals with type 2 diabetes had almost two-fold excessive risk of leg/ankle fracture in women and the pooled RR of leg/ankle fracture was 2.03 (95% CI 1.36–3.05; P = 0.0006).

Conclusions: The results of the present meta-analysis showed that individuals with type 2 diabetes mellitus had higher risk of limb fractures, and this relationship is more pronounced in leg or ankle fracture.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 23937