Meta-analysis of the effects of ischemic postconditioning on structural pathology in ST-segment elevation acute myocardial infarction

Abstract

In this meta-analysis, we assessed cardiac magnetic resonance imaging data to determine the effects of local and remote ischemic postconditioning (LPoC and RPoC, respectively) on structural pathology in ST-segmentel elevation acute myocardial infarction (STEMI).We searched the Pubmed, Embase and Cochrane Library databases up to May 2017 and included 12 randomized controlled trials (10 LPoC and 2 RPoC)containing 1069 study subjects with thrombolysis in myocardial infarction flow grade 0~1. Weighed mean difference (WMD), standardized mean difference (SMD), and odds ratio (OR) were used for the pooled analysis. Random-effect model was used for the potential clinical inconsistency. LPoC and RPoC increased the myocardial salvage index (n = 5; weighted mean difference (WMD) = 5.52; P = 0.005; I² = 76.0%), and decreased myocardial edema (n = 7; WMD = –3.35; P = 0.0009; I² = 18.0%). However, LPoC and RPoC did not reduce the final infarct size (n = 10; WMD = –1.01; P > 0.05; I² = 68.0%), left ventricular volume (n = 10; standardized mean difference = 0.23; P > 0.05; I² = 93.0%), the incidence of microvascular obstruction (n = 6; OR = 0.99; P > 0.05; I² = 0.0%) or the extent of microvascular obstruction (n = 3; WMD = –0.09; P > 0.05; I² = 6.0%). This meta-analysis shows that LPoC and/or RPoC improves myocardial salvage and decreases myocardial edema in STEMI patients without affecting final infarct size, left ventricular volume or microvascular obstruction.