Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Nils Lannes; Elisabeth Eppler; Samar Etemad; Peter Yotovski; Luis Filgueira

doi:10.18632/oncotarget.23106

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

50% on all publication fees until the end of 2024.

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Reviews:

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Nils Lannes, Elisabeth Eppler, Samar Etemad, Peter Yotovski and Luis Filgueira _

PDF | HTML | How to cite

Oncotarget. 2017; 8:114393-114413. https://doi.org/10.18632/oncotarget.23106

Metrics: PDF 3531 views | HTML 6812 views | ?

Abstract

Nils Lannes1, Elisabeth Eppler2, Samar Etemad3, Peter Yotovski1 and Luis Filgueira1

1Albert Gockel, Anatomy, Department of Medicine, University of Fribourg, CH-1700 Fribourg, Switzerland

2Pestalozzistrasse Zo, Department of BioMedicine, University of Basel, CH-4056 Basel, Switzerland

3Building 71/218 RBWH Herston, Centre for Clinical Research, The University of Queensland, QLD 4029 Brisbane, Australia

Correspondence to:

Luis Filgueira, email: [email protected]

Keywords: microglia; neuroinflammation; neurodegeneration; virus infection; brain cancer

Received: August 23, 2017 Accepted: November 15, 2017 Published: December 11, 2017

ABSTRACT

Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of neurodegenerative diseases and contribute to aging. They play an important role in sustaining and breaking the blood-brain barrier. As innate immune cells, they contribute substantially to the immune response against infectious agents affecting the CNS. They play also a major role in the growth of tumours of the CNS. Microglia are consequently the key cell population linking the nervous and the immune system. This review covers all different aspects of microglia biology and pathology in a comprehensive way.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 23106

Publication Alerts

Post-Publication Promotion

Publication Discount

Reviews:

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Abstract