Oncotarget

Research Papers:

The association analysis of TLR2 and TLR4 gene with tuberculosis in the Tibetan Chinese population

Xin Xue, Yi Qiu, Dong Jiang, Tianbo Jin, Mengdan Yan, Xikang Zhu and Yonglie Chu _

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Oncotarget. 2017; 8:113082-113089. https://doi.org/10.18632/oncotarget.22996

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Abstract

Xin Xue1,2, Yi Qiu3, Dong Jiang4, Tianbo Jin5,6, Mengdan Yan5, Xikang Zhu6 and Yonglie Chu1

1Department of Pathogen Biology and Immunology, Xi’an Jiaotong University Health Science Center, Xi’an 710061, China

2The Fourth Internal Medicine, Xi’an Chest Hospital, Xi’an TB and Thoracic Tumor Hospital, Xi’an 710100, China

3The Second Internal Medicine, Xi’an Chest Hospital, Xi’an TB and Thoracic Tumor Hospital, Xi’an 710100, China

4Inner Mongolia Medical University, Hohhot 010010, China

5Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi’an 710069, China

6School of Medicine, Xizang Minzu University, Xianyang 712082, China

Correspondence to:

Yonglie Chu, email: [email protected]

Keywords: PTB; SNP; case-control study; Tibetan Chinese population

Received: March 29, 2017    Accepted: August 06, 2017    Published: December 06, 2017

ABSTRACT

Background: The present study was undertaken to explore the relationship of Toll-like receptor (TLR) 2, TLR4 genes polymorphisms with Pulmonary tuberculosis (PTB) risk in a sample of Chinese population.

Methods: For this study, we recruited 467 subjects with PTB and 504 healthy subjects from a Tibetan population living in near or in Xi’an, China. Association analyses of single-nucleotide polymorphisms (SNPs) in TLR2 and TLR4 were performed with SPSS Statistics (version 17.0), SNPStats, Haploview (version 4.2), and SHEsis software.

Results: The research results that is association analysis of pulmonary tuberculosis show there are two increased-risk SNPs (rs7696323, OR=1.32, 95%CI =1.08-1.62, P= 0.007; rs12377632, OR=1.30, 95%CI =1.09-1.55, P= 0.004) and three decreased-risk SNPs (rs3804099, OR=0.64, 95%CI =0.52-0.79, P= 1.95*10−5; rs3804100, OR=0.67, 95%CI =0.54-0.82, P= 0.0001; rs11536889, OR=0.54, 95%CI =0.42-0.69, P= 9.14*10−7).

Conclusions: We found that two SNPs are associated with increased PTB risk and three SNPs decreased PTB risk in the Chinese Tibetan population. Our findings demonstrate an association between TLR2 and TLR4 polymorphisms and PTB.


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