Oncotarget

Research Papers:

ABCB1 3435TT and ABCG2 421CC genotypes were significantly associated with longer progression-free survival in Chinese breast cancer patients

Wanjun Li, Dan Zhang, Fen Du, Xuemei Xing, Ying Wu, Dong Xiao, Ming Liang, Zhigang Fan, Peng Zhao, Tao Liu _ and Guoyin Li

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Oncotarget. 2017; 8:111041-111052. https://doi.org/10.18632/oncotarget.22201

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Abstract

Wanjun Li1,*, Dan Zhang2,*, Fen Du3,*, Xuemei Xing4, Ying Wu5, Dong Xiao6, Ming Liang6, Zhigang Fan2, Peng Zhao7, Tao Liu8 and Guoyin Li1,9

1Department of Pathology, Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China

2Department of Oncology, Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China

3Department of Nursing, Hanzhong Vocational Technical College, Hanzhong, Shaanxi, China

4Department of Clinical Laboratory, Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China

5Department of Breast and Vascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China

6Department of General surgery, Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China

7Department of Hematology, Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China

8Department of Ophthalmology, Hanzhong 3201 Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, China

9Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi’an, Shaanxi, China

*These authors are co-first authors

Correspondence to:

Tao Liu, email: [email protected]

Guoyin Li, email: [email protected]

Keywords: breast cancer; ABCB1 C3435T and ABCG2 C421A; single nucleotide polymorphism; mutation rate; progression-free survival

Received: August 09, 2017    Accepted: September 22, 2017    Published: October 31, 2017

ABSTRACT

Objective: To investigate the distribution of ABCB1 C3435T and ABCG2 C421A gene polymorphisms in Chinese Han population and their influences on the susceptibility and prognosis of breast carcinoma.

Methods: A total of 200 female subjects were enrolled in this study, comprising 100 breast cancer patients and 100 healthy controls. Carcinoma and para-carcinoma tissues were collected from the breast cancer patients, while peripheral blood was collected from healthy controls. Single nucleotide polymorphisms (SNPs) were detected by the Taqman method. Progression-free survival (PFS) and 5-year survival rate of the patients were calculated.

Results: ABCB1 C3435T and ABCG2 C421A polymorphisms were not associated with disease susceptibility and 5-year survival rate in the study population (p>0.05). However, a high mutation rate of both ABCB1 C3435T and ABCG2 C421A (16% and 17%, respectively) was observed in breast cancer tissues. Patients with ABCB1 3435TT genotype or ABCG2 421CC genotype had longer PFS (p<0.05).

Conclusion: ABCB1 3435TT and ABCG2 421CC were significantly associated with longer PFS in Chinese breast cancer patients.


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