MAPK  and  ERK  polymorphisms are associated with PCOS risk in Chinese women

Lingmin Hu; Yiting Zhang; Li Chen; Wei Zhou; Yong Wang; Juan Wen

doi:10.18632/oncotarget.22153

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Research Papers:

MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women

Lingmin Hu, Yiting Zhang, Li Chen, Wei Zhou, Yong Wang and Juan Wen _

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Oncotarget. 2017; 8:100261-100268. https://doi.org/10.18632/oncotarget.22153

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Abstract

Lingmin Hu1,*, Yiting Zhang2,*, Li Chen1, Wei Zhou1, Yong Wang2 and Juan Wen3,4

1Department of Reproduction, The Affiliated Changzhou Maternity and Child Health Care Hospital of Nanjing Medical University, Changzhou 213003, China

2State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China

3Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China

4State Key Laboratory of Reproductive Medicine, Nanjing Maternity and Child Health Care Hospital, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China

*These authors have contributed equally to this work

Correspondence to:

Juan Wen, email: [email protected]

Keywords: variants; MAPK/ERK; RegulomeDB; polycystic ovarian syndrome

Received: June 03, 2017 Accepted: October 02, 2017 Published: October 27, 2017

ABSTRACT

In this case-control study, we analyzed the association between eight RegulomeDB-annotated single nucleotide polymorphisms (SNPs) in the MEK1, MEK2, ERK1 and ERK2 genes and polycystic ovarian syndrome (PCOS). Logistic regression analysis demonstrated that MEK1 rs12050732 (OR = 1.29 [95%CI: 1.06-1.58], P = 0.012), ERK2 rs2266966 (OR = 0.81 [95%CI: 0.67-0.99], P = 0.040) and ERK2 rs5999521 (OR = 0.66 [95%CI: 0.51-0.86], P = 0.002) were associated with PCOS risk without adjusting for age and body mass index. Moreover, PCOS risk increased with allele dosage when these three polymorphisms were combined (P_trend = 0.001). These findings suggest that genetic variants in key MAPK and ERK genes contribute to PCOS risk in Chinese women.

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Research Papers:

MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women

Abstract