Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

Vandeclecio Lira da Silva; André Faustino Fonseca; Marbella Fonseca; Thayna Emilia da Silva; Ana Carolina Coelho; José Eduardo Kroll; Jorge Estefano Santana de Souza; Beatriz Stransky; Gustavo Antonio de Souza; Sandro José de Souza

doi:10.18632/oncotarget.21715

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Research Papers:

Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

Vandeclecio Lira da Silva _, André Faustino Fonseca, Marbella Fonseca, Thayna Emilia da Silva, Ana Carolina Coelho, José Eduardo Kroll, Jorge Estefano Santana de Souza, Beatriz Stransky, Gustavo Antonio de Souza and Sandro José de Souza

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Oncotarget. 2017; 8:92966-92977. https://doi.org/10.18632/oncotarget.21715

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Abstract

Vandeclecio Lira da Silva1,2,3,*, André Faustino Fonseca1,2,3,*, Marbella Fonseca1, Thayna Emilia da Silva1, Ana Carolina Coelho1,3, José Eduardo Kroll1,3,4, Jorge Estefano Santana de Souza3,5, Beatriz Stransky3,6 Gustavo Antonio de Souza1,3 and Sandro José de Souza1,3

1Instituto do Cérebro, UFRN, Natal, Brazil

2Ph.D. Program in Bioinformatics, UFRN, Natal, Brazil

3Bioinformatics Multidisciplinary Environment (BioME), Digital Metropolis Institute, UFRN, Natal, Brazil

4Instituto de Bioinformática e Biotecnologia, Natal, Brazil

5Instituto Metrópole Digital, UFRN, Natal, Brazil

6Departmento de Engenharia Biomédica, UFRN, Natal, Brazil

*These authors have contributed equally to this work

Correspondence to:

Sandro José de Souza, email: [email protected]

Keywords: cancer/testis, cancer antigens, biomarkers, prognosis

Received: June 03, 2017 Accepted: August 17, 2017 Published: October 10, 2017

ABSTRACT

Cancer/testis (CT) genes are excellent candidates for cancer immunotherapies because of their restrict expression in normal tissues and the capacity to elicit an immune response when expressed in tumor cells. In this study, we provide a genome-wide screen for CT genes with the identification of 745 putative CT genes. Comparison with a set of known CT genes shows that 201 new CT genes were identified. Integration of gene expression and clinical data led us to identify dozens of CT genes associated with either good or poor prognosis. For the CT genes related to good prognosis, we show that there is a direct relationship between CT gene expression and a signal for CD8+ cells infiltration for some tumor types, especially melanoma.

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Research Papers:

Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

Abstract