Bone marrow stem cells-derived extracellular matrix is a promising material

Xiaoyan Wang; Guanghua Chen; Chao Huang; Hualei Tu; Jilong Zou; Jinglong Yan

doi:10.18632/oncotarget.21683

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Research Papers:

Bone marrow stem cells-derived extracellular matrix is a promising material

Xiaoyan Wang, Guanghua Chen, Chao Huang, Hualei Tu, Jilong Zou and Jinglong Yan _

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Oncotarget. 2017; 8:98336-98347. https://doi.org/10.18632/oncotarget.21683

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Abstract

Xiaoyan Wang1,2, Guanghua Chen1,2, Chao Huang1, Hualei Tu3, Jilong Zou4 and Jinglong Yan1

1Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P.R. China

2Key Laboratory of the Ministry of Education, Ministry of Myocardial Ischemia, Harbin 150086, P.R. China

3Burn Department, The Fifth Hospital of Harbin, Harbin 150086, P.R. China

4Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, P.R. China

Correspondence to:

Jinglong Yan, email: [email protected]

Keywords: extracellular matrix, BMSCs, tissue engineering, scaffold, bone regeneration

Received: August 24, 2017 Accepted: September 20, 2017 Published: October 09, 2017

ABSTRACT

The extracellular matrix(ECM), which is primarily composed of collagens and proteoglycans, plays a key role in cell proliferation, differentiation, and migration and interactions between cells. In this study, we produced chitosan/gelatin/bone marrow stem cells-derived extracellular matrix(C/G/BMSCs-dECM) scaffolds via lyophilization and cross-linking, and chitosan/gelatin(C/G) scaffolds were used as controls. For the C/G/BMSCs-dECM scaffolds, the average pore size was 289.17 ± 80.28 μm; the average porosity was 89.25 ± 3.75%; the average compressive modulus was 0.82 ± 0.07 MPa; and the average water uptake ratio was 13.81 ± 1.00. In vitro, the C/G/BMSCs-dECM scaffolds promoted bone marrow stem cells(BMSCs) attachment and proliferation. Moreover, improved osteogenic differentiation was observed for these scaffolds. Thus, C/G/BMSCs-dECM is a promising material for bone tissue engineering.

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Research Papers:

Bone marrow stem cells-derived extracellular matrix is a promising material

Abstract