Oncotarget

Research Papers:

Comparison of gross tumor volume of primary oesophageal cancer based on contrast-enhanced three-dimensional, four-dimensional, and cone beam computed tomography

Chao-Yue Hu, Jian-Bin Li _, Jin-Zhi Wang, Wei Wang, Feng-Xiang Li and Yan-Luan Guo

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Oncotarget. 2017; 8:95577-95585. https://doi.org/10.18632/oncotarget.21520

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Abstract

Chao-Yue Hu1,2, Jian-Bin Li2, Jin-Zhi Wang2, Wei Wang2, Feng-Xiang Li2 and Yan-Luan Guo2

1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong Province, China

2Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province, China

Correspondence to:

Jian-Bin Li, email: [email protected]

Keywords: oesophageal cancer, three-dimensional computed tomography, four-dimensional computed tomography, cone beam computed tomography, gross tumor volume

Received: April 13, 2017     Accepted: September 19, 2017     Published: October 05, 2017

ABSTRACT

Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV.

Results: Independent of tumor location, significant differences were observed among volumes [IGTV10 > (IGTVCBCT or IGTVMIP) > (GTV3D or GTV4D50)]. The underestimations or overestimations between IGTV10 and IGTVCBCT were larger than those between IGTV10 and IGTVMIP (p < 0.001–0.011; p < 0.001–0.023). For upper oesophageal tumors, GTV4D50/IGTVCBCT negatively correlated with motion vector (r = –0.756, p = 0.011). In AP direction, the centroid coordinates of IGTVCBCT differed from GTV3D, GTV4D50, IGTVMIP and IGTV10 (p = 0.006, 0.013, 0.038, and 0.010). For middle oesophageal tumors, IGTV10/IGTVCBCT positively correlated with motion vector (r = 0.695, p = 0.006). The centroid coordinates of IGTVCBCT differed from those of IGTV10 (p = 0.046) in AP direction. For distal oesophageal tumors, the centroid coordinates of IGTVCBCT showed significant differences to those of IGTVMIP (p = 0.042) in LR direction. For both middle and distal tumors, the degrees of associations of IGTV10 outside IGTVCBCT significantly correlated with the motion vector (r = 0.540, p = 0.046; r = 0.678, p = 0.031).

Materials and Methods: Thirty-four oesophageal cancer patients underwent 3DCT, 4DCT and CBCT. GTV3D, GTV4D50, internal GTVMIP (IGTVMIP) and IGTVCBCT were delineated on 3DCT, 4DCT50, 4DCTMIP and CBCT. GTVs from 10 respiratory phases were combined to produce GTV10. Differences in volume, position for different targets, correlation between volume ratio and motion vector were evaluated. The motion vector was the spatial moving of the target centroid position.

Conclusions: IGTVCBCT encompasses more motion information than GTV3D and GTV4D50 for upper oesophageal tumors, but slightly less than IGTV10 for middle and distal oesophageal tumors. IGTVCBCT incorporated similar motion information to IGTVMIP. However, motion information encompassed in CBCT and MIP cannot replace each other.


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