Oncotarget

Meta-Analysis:

Exogenous melatonin in the treatment of pain: a systematic review and meta-analysis

Chaojuan Zhu, Yunyun Xu, Yonghong Duan, Wei Li, Li Zhang, Yang Huang, Wei Zhao, Yutong Wang, Junjie Li, Ting Feng, Xiaomei Li, Xuehui Hu and Wen Yin _

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Oncotarget. 2017; 8:100582-100592. https://doi.org/10.18632/oncotarget.21504

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Abstract

Chaojuan Zhu1,2,*, Yunyun Xu1,*, Yonghong Duan1,*, Wei Li3, Li Zhang1, Yang Huang1, Wei Zhao1, Yutong Wang1, Junjie Li1, Ting Feng1, Xiaomei Li4, Xuehui Hu2,5 and Wen Yin1

1Department of Emergency Medicine, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China

2Department of Nursing, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China

3Department of Human Anatomy, Histology and Embryology, The Fourth Military Medical University, Xi’an 710032, China

4Faculty of Nursing, College of Medicine, Xi'an Jiaotong University, Xi’an 710049, China

5Department of Dermatology, Xijing Hospital, The Fourth Military Medical University, Xi’an 710032, China

*These authors contributed equally to this work

Correspondence to:

Wen Yin, email: [email protected]

Xuehui Hu, email: [email protected]

Keywords: melatonin, pain, brain-derived neurotrophic factor, meta-analysis

Received: August 09, 2017     Accepted: September 20, 2017     Published: October 05, 2017

ABSTRACT

Melatonin is an important hormone for regulating mammalian circadian biology and cellular homeostasis. Recent evidence has shown that melatonin exerts anti-nociception effects in both animals and humans. However, according to clinical trials, the anti-nociception effects of melatonin are still controversial. The aim of this meta-analysis was to investigate the anti-nociception effects of melatonin premedication. The primary outcome was the effects of melatonin on pain intensity. The secondary outcomes included the number of patients with analgesic requirements, total analgesic consumption, and brain-derived neurotrophic factor (BDNF) levels. In total, 19 studies were included in the current meta-analysis. The pooling data show that melatonin significantly decreased the pain intensity, as evidenced by the pain scores. Moreover, melatonin administration also reduced the proportion of patients with analgesic requirements and BDNF levels. However, the effects of melatonin on total analgesic consumption still require further confirmation. Collectively, the current meta-analysis supports the use of melatonin for anti-nociception.


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