Myeloid ecotropic viral integration site 1 inhibits cell proliferation, invasion or migration in human gastric cancer

Fei Song; Hong Wang; Yingying Wang

doi:10.18632/oncotarget.21376

Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial, Introducing Oncotarget.

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. Papers will now be published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Subscribe to receive alerts once a paper has been published by Oncotarget.

Learn about our FREE

Post-Publication Promotion Services

Impact Journals, LLC is the publisher of Oncotarget: www.impactjournals.com.

Impact Journals is a member of the Wellcome Trust List of Compliant Publishers.

Impact Journals is a member of the Society for Scholarly Publishing.

On December 23, 2022, Oncotarget server experienced a DDoS attack. As a result, Oncotarget site was inaccessible for a few hours. Oncotarget team swiftly dealt with the situation and took it under control. This malicious action will be reported to the FBI.

Research Papers:

This article has been retracted. Retraction in: Oncotarget. 2024; 15:634-634.

Myeloid ecotropic viral integration site 1 inhibits cell proliferation, invasion or migration in human gastric cancer

Fei Song, Hong Wang and Yingying Wang _

PDF | HTML | How to cite

Oncotarget. 2017; 8:90050-90060. https://doi.org/10.18632/oncotarget.21376

Metrics: PDF 1440 views | HTML 2444 views | ?

Abstract

Fei Song1, Hong Wang1 and Yingying Wang2

1Department of General Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, China

2Department of Gynecologic Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong, China

Correspondence to:

Yingying Wang, email: [email protected]

Keywords: MEIS1, gastric cancer, proliferation, invasion, migration

Received: June 27, 2017 Accepted: September 05, 2017 Published: September 28, 2017

ABSTRACT

Myeloid ecotropic viral integration site 1 (MEIS1) has been identified to be a potential tumor suppressor in some cancers. However, the mechanisms underlying MEIS1-induced cancer development and progression were not clear. Here, we investigated the expression and role of MEIS1 in gastric cancer. In vivo, we analyzed tumor growth using nude mice model. In the present study, MEIS1 expression was obviously decreased in GC cell lines compared with that in normal gastric cell lines (all p<0.001). MEIS1 overexpression inhibited cell proliferation and G1/S transition accompanied by decreased Cyclin D1 and Cyclin A expression. Furthermore, MEIS1 overexpression decreased the expression of Survivin, and induced cell apoptosis (p<0.001). Transwell migration assay revealed that MEIS1 affects cell invasion and migration, and inhibited epithelial-mesenchymal transition (EMT). Finally, MEIS1 inhibits MKN28 cell growth in nude mice model. In conclusion, our study suggested that MEIS1 plays an important role in regulating cell survival, proliferation, anchorage-independent growth, cell cycle, apoptosis and metastasis. Thus, MEIS1 might be recommended as an effective target for GC patients.

All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 21376

Publication Alerts

Post-Publication Promotion

Research Papers:

Myeloid ecotropic viral integration site 1 inhibits cell proliferation, invasion or migration in human gastric cancer

Abstract